ProspEctive First Evaluation in Chest Pain Trial (PERFECT)
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ClinicalTrials.gov Identifier: NCT01604655 |
Recruitment Status
:
Completed
First Posted
: May 24, 2012
Last Update Posted
: March 8, 2016
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Chest Pain Shortness of Breath Suspected Acute Coronary Syndrome | Procedure: Coronary CT Angiography Procedure: Stress Test | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 411 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Diagnostic |
Official Title: | ProspEctive Randomized First Evaluation in Chest Pain Trial |
Study Start Date : | September 2011 |
Actual Primary Completion Date : | December 2013 |
Actual Study Completion Date : | December 2015 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Coronary CT Angiography
Patient admitted with chest pain is randomized to CCTA for assessment.
|
Procedure: Coronary CT Angiography
CCTA
|
Active Comparator: Stress Test
Patients admitted with chest pain are randomized to a stress test (stress SPECT or Echocardiography) for assessment.
|
Procedure: Stress Test
Stress Test
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- Time to discharge [ Time Frame: Initial hospitalization ]
- Change in medical regimen [ Time Frame: Initial hospitalization ]
- Downstream cardiovascular testing and hospitalization [ Time Frame: 2 years ]
- All-cause mortality [ Time Frame: 7 days, 30 days, 6, 12, and 24 months. ]This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.
- Cardiovascular mortality [ Time Frame: 7 days, 30 days, 6, 12, and 24 months. ]This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.
- Non-fatal myocardial infarction [ Time Frame: 7 days, 30 days, 6, 12, and 24 months. ]This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.

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Ages Eligible for Study: | 45 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with chest pain or SOB admitted for rule out acute coronary syndrome
- Age ≥45 years
- EKG non-diagnostic for acute coronary syndrome
- At least 1 set of negative troponin I
Exclusion Criteria:
- Patient with ST elevation myocardial infarction.
- Patients with non-ST elevation myocardial infarction.
- Patients with known CAD.
- Patients with serum creatinine > 1.5.
- Atrial fibrillation or marked irregular heart rhythm.
- Patients in whom heart rate cannot be controlled.
- Patient with allergies to iodinated contrast agents.
- Pregnant women
- Patients unable to give informed consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01604655
United States, New York | |
St. Luke's and Roosevelt Hospitals | |
New York, New York, United States, 10025 |
Principal Investigator: | Seth Uretsky, MD | St. Luke's and Roosevelt Hospital Centers |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | St. Luke's-Roosevelt Hospital Center |
ClinicalTrials.gov Identifier: | NCT01604655 History of Changes |
Other Study ID Numbers: |
11-307 |
First Posted: | May 24, 2012 Key Record Dates |
Last Update Posted: | March 8, 2016 |
Last Verified: | March 2016 |
Keywords provided by St. Luke's-Roosevelt Hospital Center:
Chest pain shortness of breath suspected acute coronary syndrome stress testing coronary computed tomography angiography |
Additional relevant MeSH terms:
Acute Coronary Syndrome Chest Pain Dyspnea Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases |
Pain Neurologic Manifestations Nervous System Diseases Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory |