Imaging Biomarkers of Tissue Microstructure and Vasculature as Predictors of Glioblastoma Multiforme
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|ClinicalTrials.gov Identifier: NCT01604590|
Recruitment Status : Completed
First Posted : May 23, 2012
Last Update Posted : April 13, 2015
|Condition or disease||Intervention/treatment|
|Glioblastoma||Radiation: Magnetic Resonance Imaging (MRI)|
This study is for subjects with a diagnosis of a brain tumor called glioblastoma that is being treated with bevacizumab. Bevacizumab is a drug that your doctor believes is the best treatment option available to subjects at this time for this type of tumor. Bevacizumab affects the growth of blood vessels by tumors such as glioblastoma, thus effectively starving the tumor of oxygen and food.
Magnetic Resonance Imaging (MRI) is a test done by a machine in the radiology department that takes pictures of your body using special magnets, rather than X-rays. With a new MRI scan technique the investigators can take very, very detailed images of the vessel and tumor structure. This project will allow us to compare the images of vessel and tumor structure to the effectiveness of Bevacizumab as a treatment option. With this project the investigators will hopefully develop an accurate way to predict whether or not Bevacizumab will be an effective treatment option for patients.
|Study Type :||Observational|
|Actual Enrollment :||13 participants|
|Official Title:||Imaging Biomarkers of Tissue Microstructure and Vasculature as Predictors of Glioblastoma Multiforme Response to Treatment With Bevacizumab for Progressive Disease|
|Study Start Date :||July 2012|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||September 2014|
|glioblastoma patients on bevacizumab||
Radiation: Magnetic Resonance Imaging (MRI)
Magnetic Resonance Imaging (MRI) will be used to compare bevacizumab to the images of vessel and tumor structure.
- MRI to show differences between bevacizumab responses [ Time Frame: 1 month ]The MRI parameters will help show the differences between bevacizumab-responsive and bevacizumab non-responsive recurrent glioblastoma
- Progression Free Survival at 3 months [ Time Frame: 3 months ]The progression of the subject's disease will be evaluated at 3 months.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01604590
|United States, South Carolina|
|Medical University of South Carolina|
|Charleston, South Carolina, United States, 29425|
|Principal Investigator:||Pierre Giglio, MD||Medical University of South Carolina|