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Membrane Shedding During Septic Shock

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01604551
First Posted: May 23, 2012
Last Update Posted: June 1, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
  Purpose
Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

Condition
Septic Shock

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Enrollment: 100
Study Start Date: May 2003
Study Completion Date: December 2011
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with septic shock
Criteria

Inclusion Criteria:

  • Septic shock
  • Informed consent

Exclusion Criteria:

  • Class IV heart failure
  • Child-Plugh grade C cirrhosis
  • Cancer under active treatment
  • BMI>35 kg/m²
  • Moribund patient
  • DNR decision
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01604551


Locations
France
Service Réanimation Médicale et Médecine Hyperbare, CHU
Angers, France, 49933
Centre Hospitalier
Mulhouse, France, 68070
Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Principal Investigator: Xavier DELABRANCHE, MD Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, France
  More Information

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT01604551     History of Changes
Other Study ID Numbers: 4649
First Submitted: May 21, 2012
First Posted: May 23, 2012
Last Update Posted: June 1, 2012
Last Verified: May 2012

Additional relevant MeSH terms:
Shock
Shock, Septic
Pathologic Processes
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation