European Transfusion Practice and Outcome Study (ETPOS)
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ClinicalTrials.gov Identifier: NCT01604083 |
Recruitment Status :
Completed
First Posted : May 23, 2012
Last Update Posted : May 1, 2019
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Condition or disease |
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Surgery Erythrocyte Transfusion Habits Anemia Blood Coagulation Disorders |
In European patients undergoing elective non-cardiac surgery receiving at least one PRBC(packed red blood cells) during their surgery it is proposed to:
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Evaluate evidence of differences in the standard of peri-operative transfusion care in different healthcare systems within Europe, and the use of blood conserving techniques.
- Evaluate the ratio of transfusion of PRBC to blood products in the operating room
- Evaluate which factors determine transfusion of PRBC (is it patient's haemodynamics / haemoglobin threshold/ pressure from the surgeon / acute brisk bleeding / else) and blood products (ratio to PRBC / POC (point of care) monitoring/ per protocol/ else) in the operating room
- Evaluate whether there are factors in transfusion therapy that are associated with outcome (in-hospital mortality and unplanned admission to ICU(Intensive Care Unit).)
Study Type : | Observational |
Actual Enrollment : | 6066 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | European Transfusion Practice and Outcome Study A Multi-central Evaluation of Standard of Transfusion Care and Clinical Outcome for Elective Surgical Patients. Observational Study. |
Study Start Date : | April 2013 |
Actual Primary Completion Date : | October 2013 |
Actual Study Completion Date : | December 2013 |

- Amount of PRBC and blood products and coagulation factors transfused [ Time Frame: The Time point at which outcome measure is assessed is during surgery at Day 0 ]Amount of packed red blood cells and blood products and coagulation factors: fresh frozen plasmas (FFPs), platelets (PTs) and tranexamic acid transfused
- Factors determining transfusion of PRBC and blood products in different regions of Europe [ Time Frame: The Time point at which outcome measure is assessed is during surgery at Day 0 ]Reasons for transfusion of PRBC(packed red blood cells)and blood products in different regions of Europe
- 30-day mortality [ Time Frame: The Time point at which outcome measure is assessed is at Day 30 after Surgery ]Assesses on Day 30 whether patient is still alive or has died between day zero (Surgery) day 30 after surgery
- Unplanned admission to the ICU [ Time Frame: The Time point at which outcome measure is assessed is at Day 30 after Surgery ]Assesses on day 30 whether the patient had a Unplanned admission to the Intensive care unit(ICU) following surgery (day 0) until the day 30
- Type and frequency of usage of blood conserving techniques [ Time Frame: The Time point at which outcome measure is assessed is at Day 0, on Surgery Day ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- patients undergoing elective non-cardiac surgery commencing during the three-month period and who received at least one erythrocyte concentrate during their intra-operative stay.
Exclusion Criteria:
- Age < 18 years
- cardiothoracic surgery
- emergency trauma patients

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01604083
Croatia | |
University hospital "Merkur" | |
Zagreb, Croatia | |
Czechia | |
Faculty Hospital Brno | |
Brno, Czechia | |
Estonia | |
North Estonian Center | |
Tallinn, Estonia | |
Germany | |
University Hospital Tübingen University, Germany | |
Tübingen, Germany | |
Greece | |
Aretaieion University Hospital | |
Athens, Greece | |
Israel | |
Tel Aviv Medical Center | |
Tel Aviv, Israel | |
Spain | |
Hospital Vall d Hebron | |
Barcelona, Spain | |
Hospital Clínico Universitario de Valencia | |
Valencia, Spain | |
Sweden | |
Sahlgrenska University Hospital | |
Göteborg, Sweden |
Study Chair: | Jens Meier, MD | General Hopsital Linz, Linz, Austria |
Other Publications:
Responsible Party: | European Society of Anaesthesiology |
ClinicalTrials.gov Identifier: | NCT01604083 |
Other Study ID Numbers: |
ETPOS |
First Posted: | May 23, 2012 Key Record Dates |
Last Update Posted: | May 1, 2019 |
Last Verified: | April 2016 |
transfusion packed red blood cells (PRBC) Transfusion Practice Transfusion habits Outcome |
elective surgery ETPOS ESA European Society of Anaesthesiology |
Hemostatic Disorders Blood Coagulation Disorders Hematologic Diseases |
Vascular Diseases Cardiovascular Diseases Hemorrhagic Disorders |