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To Evaluate The Anrogens and Ovary Function in In Vitro Fertilization

This study has suspended participant recruitment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01600794
First Posted: May 17, 2012
Last Update Posted: May 17, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Ming-I Hsu, Taipei Medical University WanFang Hospital
  Purpose

Because the society convention is changed, people are late for getting married, leading to increasing the bearing age in women. According to the previous study, if the age is over 30, the oocyte number in ovary has left only 10% and 3% in over 40 years old. The data is collected by Bureau of Health Promotion, Department of Health shows that there are about 7000 people treating the infertility and it spends about 150000 to 250000 NT dollars in every in vitro fertilization (IVF) cycle, but the live birth rate is only 30%. So it is important to know how to estimate and approve the ovary function that lead to increase the live birth rate. The investigators plan to estimate the correlation between the serum androgens levels and pregnancy outcome in the women who have infertility problem. Furthermore, for the repeated IVF cycle, the ovary function might be re-evlauated because of the possible effect from stimulated drugs used on previous cycle. It's important to understand the ovary function for IVF patient to choose the appropriate drugs and dose.

The investigators use blood and clinical test to analyze, the items for analysis are below:

  1. Routine blood test: FSH、LH、E2、P4、Anti-Mullerian Hormone(AMH)、
  2. Studied blood test: Inhibin B、total testosterone (TT)、Androstenedione、DHEA-S
  3. Clinical test: Ultrasound
  4. Personal condition. In order to finishing the test, every patient will be asked to collect about 10 to 15 cc blood for the research.

Condition
In Vitro Fertilization

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: To Evaluate The Androgens and Ovary Function Impact on The Pregnancy Outcome in In Vitro Fertilization

Further study details as provided by Ming-I Hsu, Taipei Medical University WanFang Hospital:

Estimated Enrollment: 1000
Study Start Date: October 2011
Estimated Study Completion Date: October 2012
Groups/Cohorts
male/female, immunity or others factor infertility, IVF

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
This study include the patients who are evaluated by the doctors and are sure to process the IVF cycle.
Criteria

Inclusion Criteria:

  • This study include the patients who are evaluated by the doctors and are sure to process the IVF cycle.

Exclusion Criteria:

  • This study exclude the patients who are not evaluated by the doctors and are not sure to process the IVF cycle.
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Ming-I Hsu, Taipei Medical University WanFang Hospital
ClinicalTrials.gov Identifier: NCT01600794     History of Changes
Other Study ID Numbers: WFH-TMU-IVF-201107012
First Submitted: May 14, 2012
First Posted: May 17, 2012
Last Update Posted: May 17, 2012
Last Verified: May 2012

Keywords provided by Ming-I Hsu, Taipei Medical University WanFang Hospital:
In Vitro Fertilization (IVF)
androgens
ovary function
This study include the patients who are evaluated by the doctors and are sure to process the In Vitro Fertilization cycle.

Additional relevant MeSH terms:
Androgens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs