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Resistance Exercise in Rheumatic Disease

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2015 by Johns Hopkins University
Information provided by (Responsible Party):
Rebecca L Manno, Johns Hopkins University Identifier:
First received: May 7, 2012
Last updated: December 22, 2015
Last verified: December 2015
People with rheumatic disease often have decreased strength, muscle mass, and bone mineral density due to repeated bouts of inflammation, normal effects of aging, disuse, and inactivity. The medications used to quell the disease process, such as prednisone, can also have detrimental effects on body composition, strength, and functional capacity. The investigators propose to investigate the feasibility, safety, and effects of resistance exercise in older patients with rheumatoid arthritis (RA) and vasculitis. The unique resistance protocol the investigators propose involves performing movements in a slow and controlled fashion (i.e., no acceleration or use of momentum in the lifting and lowering of the resistance) to minimize force on the joints and connective tissues. This will be conducted in an individually-supervised environment with a new generation of exercise equipment that will accommodate their musculoskeletal capabilities and allow for reproducibility of the exercise protocol. The investigators intend to investigate the feasibility, safety, musculoskeletal, and psychological effects of this resistance exercise protocol in older patients with rheumatoid arthritis and vasculitis by testing their strength, body composition, functional ability, mood, and quality of life before and after this 16-week resistance exercise intervention.

Condition Intervention
Rheumatoid Arthritis
Systemic Vasculitis
Other: Resistance Exercise

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Resistance Exercise in Rheumatic Disease

Resource links provided by NLM:

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • Safety [ Time Frame: 16 weeks ]

    To ensure safety and tolerance of a resistance exercise protocol for patients with systemic

    vasculitis or rheumatoid arthritis. We will measure disease activity before and after each exercise session to determine if there is an association with the exercise program. We will track any major (and minor) injuries which are attributed to the exercise progrm.

Secondary Outcome Measures:
  • Change in Body composition after 16 weeks of resistance exercise [ Time Frame: 16 weeks ]
    To assess change in body composition associated with this resistance exercise protocol (after 16 weeks).

  • Change in Strength after 16 weeks of resistance exercise [ Time Frame: 16 weeks ]
    We will test if strength increases before and after the exercise intervention

  • Change in Functional status after 16 weeks of resistance exercise [ Time Frame: 16 weeks ]
    We will determine if functional status, as measured by the short physical performance battery, improves after 16 weeks

  • Change in inflammatory cytokines (CRP, ESR, IL6) after 16 weeks of resistance exercise [ Time Frame: 16 weeks ]
    Participants will have blood drawn before and after 16 weeks of exercise to determine if changes have occurred in their inflammatory cytokines.

Estimated Enrollment: 10
Study Start Date: May 2012
Estimated Study Completion Date: July 2017
Estimated Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Resistance Exercise
Subjects will participate in a 16 week long resistance exercise program which will consist of 2 30-minute individually supervised sessions per week.
Other: Resistance Exercise
Two 30-minute individually supervised exercise sessions per week for 16-weeks


Ages Eligible for Study:   45 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • diagnosis of rheumatoid arthritis OR systemic vasculitis (defined as granulomatosis with polyangiitis, Churg-Strauss, microscopic polyangiitis, ANCA-associated vasculitis, or giant cell arteritis)

Exclusion Criteria:

  • Non-English speaking
  • Pregnancy
  • Absolute cardiac or pulmonary contraindication to exercise
  • pacemaker
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01599260

Contact: Rebecca Manno, MD 410-550-0722

United States, Maryland
Johns Hopkins Bayview Medical Campus Recruiting
Baltimore, Maryland, United States, 21224
Contact: Rebecca Manno, MD    410-550-0722      
Sponsors and Collaborators
Johns Hopkins University
  More Information

Responsible Party: Rebecca L Manno, Assistant Professor of Medicine, Johns Hopkins University Identifier: NCT01599260     History of Changes
Other Study ID Numbers: NA_00069415
Study First Received: May 7, 2012
Last Updated: December 22, 2015

Additional relevant MeSH terms:
Systemic Vasculitis
Arthritis, Rheumatoid
Rheumatic Diseases
Collagen Diseases
Joint Diseases
Musculoskeletal Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on May 23, 2017