This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

This study has been completed.
Information provided by (Responsible Party):
Esben Thyssen Vestergaard, University of Aarhus Identifier:
First received: May 7, 2012
Last updated: January 15, 2013
Last verified: January 2013
The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Condition Intervention Phase
Healthy Drug: Acyl ghrelin Drug: Placebo (Ringer acetate) Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Local Metabolic Effects of Ghrelin: A Clinical Microdialysis Study

Further study details as provided by Esben Thyssen Vestergaard, University of Aarhus:

Primary Outcome Measures:
  • Interstitial concentrations of glycerol [ Time Frame: Interstitial concentrations of glycerol at t=120 minutes ]

Secondary Outcome Measures:
  • Interstitial concentrations of lactate [ Time Frame: Interstitial concentrations of lactate at t=120 minutes ]
  • Interstitial concentrations of glucose [ Time Frame: Interstitial concentrations of glucose at t=120 minutes ]

Enrollment: 10
Study Start Date: June 2012
Study Completion Date: January 2013
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Ghrelin
Drug: Acyl ghrelin
Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes
Other Names:
  • Human acyl ghrelin
  • Ghrelin
Placebo Comparator: Placebo
Ringer acetate is used for placebo.
Drug: Placebo (Ringer acetate)
Ringer acetate 2 microliter/min for 300 minutes


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy male
  • age 18-65 years (included)
  • Body mass index 20-25 (included)

Exclusion Criteria:

  • alcohol abuse
  • malignant disease
  • use of any medicine except otc painkillers
  • any disease recognized
  • participation in a trial using radioactive isotopes within the last 6 months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01595373

Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
Esben Thyssen Vestergaard
Principal Investigator: Esben T. Vestergaard, MD PhD University of Aarhus
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Esben Thyssen Vestergaard, Postdoc PhD, University of Aarhus Identifier: NCT01595373     History of Changes
Other Study ID Numbers: 2012-28512
Study First Received: May 7, 2012
Last Updated: January 15, 2013

Keywords provided by Esben Thyssen Vestergaard, University of Aarhus:
Metabolic effects of ghrelin processed this record on September 21, 2017