Metformin in Pregnancy in Women With Polycystic Ovary Syndrome
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ClinicalTrials.gov Identifier: NCT01594697
Recruitment Status :
First Posted : May 9, 2012
Last Update Posted : May 11, 2012
Catholic University of the Sacred Heart
Information provided by (Responsible Party):
Maurizio Guido, Catholic University of the Sacred Heart
The study provide a detailed longitudinal evaluation of the gluco-insulinemic assessment of pregnant PCOS women under metformin treatment. 47 non diabetic Polycystic Ovary Syndrome (PCOS) women became pregnant during metformin treatment and continued taking the drug during gestation. An oral glucose tolerance test and euglycaemic hyperinsulinaemic clamp were performed at each trimester of gestation.
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Ages Eligible for Study:
18 Years to 40 Years (Adult)
Sexes Eligible for Study:
age 18-40 yr,
metformin treatment for at least 3 months before entering the pregnancy,
gestational age between 5 and 12 wk
significant liver or renal impairment
neoplasms and other endocrine diseases
the use of drugs other than metformin able to interfere with glucose and insulin metabolism.