Behavior During Experimentally Induced Pain
Numerous factors can influence the processing of pain message: the affective or emotional, the sensorial and the cognitive components. Interindividual variations at the emotional and cognitive levels may interfere with the pain message and the consecutive behavior. Some modifications in these components are observed in psychiatric troubles, but their influences on the behavior to pain have not been studied, although they have been studied in some populations characterized as non communicating, with obvious cognitive degradations (subject with dementia, older, newborns,…).In an other study in course, the past pain experience is explored in relation to results to experimental pain tests, emotional and anxious characteristics. This present pilot study aims at studying the infra-verbal behavioural signs during experimentally induced pain in subjects with schizophrenia, major depression, and controls.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||Behavior During Experimentally Induced Pain|
- Frequency of behavioral signs [ Time Frame: during pain tests (average 1 hour) ] [ Designated as safety issue: No ]number of corporal mobility, facial expression and sound indicators
|Study Start Date:||April 2012|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
No Intervention: diagnosis
diagnosis according to the DSM-IV-TR : major depression and schizophrenia, or control.
Other: pain tests
pain induction with pressure application or ischemia on the arm
The objective is to search for behavioral non verbal indicators of pain during experimentally induced pain (pressure application, ischemia induction).
Included subjects are subjected to experimental pain tests : pressure application (160 kPa) with an algometer to determine the pain with Visual Analogic Scale (VAS), and ischemia induction to determine the time needed to feel pain with an intensity equivalent to 3 with the VAS.
Subjects are filmed during experimentation to identify the corporal mobility signs, facial expression signs and sonorous signs associated to pain stimulation.
Neurophysiological measures complete these observations : surface electromyogram, heart rate measure, blood pressure.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01594528
|Centre Hospitalier Esquirol|
|Limoges, France, 87025|
|Principal Investigator:||Dominique Malauzat, MD||Centre Hospitalier Esquirol|