Acute Effects of Exercise in Women With Fibromyalgia (FM)
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|ClinicalTrials.gov Identifier: NCT01592916|
Recruitment Status : Completed
First Posted : May 7, 2012
Last Update Posted : February 2, 2018
The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM.
Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||55 participants|
|Official Title:||Acute Effects of Exercise in Women With FM|
|Actual Study Start Date :||May 10, 2012|
|Actual Primary Completion Date :||November 23, 2012|
|Actual Study Completion Date :||November 23, 2012|
Women with fibromyalgia, aged 20-50 years
Women without severe disease, aged 20-50 years
- IGF1 level [ Time Frame: 15 min ]Ergometer cycle test of 15 minutes at low respective high intensity. Blood test is done before and after exercise. Change in quantity of IGF1 is measured.
- Pain rating [ Time Frame: 15 minutes ]Pain is rated by the test person before and after the ergometer cycle test.
- Pain threshold [ Time Frame: 15 minutes ]Pain threshold is measured before and after the ergometer test.
- Interleukin 6 and 8 [ Time Frame: 15 minutes ]Blood test is done before and after the ergometer bicycle test. Quantity of interleukin 6 and 8 is measured.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01592916
|Sahlgrenska University Hospital, Dept of Physical Therapy|
|Göteborg, Sweden, 41345|
|Principal Investigator:||Kaisa Mannerkorpi, Assoc prof||Göteborg University|