Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study

Study Description

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Infants with heterotaxy syndrome (HS) are born with an abnormal arrangement of organs along the right-left body axis. Abnormalities of intestinal rotation and fixation are commonly associated with HS. Malrotation is the most worrisome intestinal rotation abnormality (IRA). Advances in cardiac surgery have improved HS mortality such that there is increasing attention to IRA and their management. The objective of this research project is to prospectively observe a cohort of infants with HS and IRA and evaluate their long term outcomes. Specifically, the investigators would like to determine what is the natural history of asymptomatic IRA in patients with HS and what is the morbidity and mortality secondary to an elective Ladd procedure for asymptomatic IRA in a population with HS? The investigators plan a prospective, multi-center, observational study to follow this complicated group of patients. This will be a web-based database collected from major cardiac tertiary care centers in both Canada and the United States. Patients with HS will be recruited by their primary site and clinical data will be collected by their primary site prospectively throughout childhood until they are at least five years of age. This patient population will be followed by their own clinical care givers; this is not an interventional study. No additional clinic visits will be required and the patients will not have to be contacted. Patient medical records will be accessed by a member of the study team at the primary site at least once per year or more frequently if interventions are required or complications develop.

Condition or disease
Heterotaxy Syndrome

Study Design

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Observational
Actual Enrollment :	40 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study
Study Start Date :	March 2012
Actual Primary Completion Date :	December 2016
Actual Study Completion Date :	December 2016

Groups and Cohorts

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort
Infants with heterotaxy syndrome

Outcome Measures

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Midgut volvulus [ Time Frame: First year of life ]

Secondary Outcome Measures :

1. Morbidity secondary to a prophylactic Ladd procedure [ Time Frame: Post Ladd procedure ]
2. Mortality secondary to a prophylactic Ladd procedure [ Time Frame: Within one month of Ladd procedure ]

Eligibility Criteria

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	up to 6 Months (Child)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

All infants with heteterotaxy syndrome whose families provide written informed consent.

Criteria

Inclusion Criteria:

• All infants less than or equal to six months of age with a new diagnosis of heterotaxy syndrome

Exclusion Criteria:

Contacts and Locations

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

Canada, Alberta
Stollery Children's Hospital
Edmonton, Alberta, Canada, T6G 2B7

Sponsors and Collaborators

University of Alberta

Investigators

Principal Investigator:	Lindsay Ryerson, MD	University of Alberta

More Information

Go to 

Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party:	Lindsay Ryerson, Assistant Professor, University of Alberta
ClinicalTrials.gov Identifier:	NCT01591928 History of Changes
Other Study ID Numbers:	2012-LR-01
First Posted:	May 4, 2012
Last Update Posted:	May 9, 2017
Last Verified:	May 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:	No

Keywords provided by Lindsay Ryerson, University of Alberta:

Pediatrics; Congenital heart disease; Heterotaxy syndrome; Intestinal malrotation

Additional relevant MeSH terms:

Heterotaxy Syndrome; Syndrome; Disease; Pathologic Processes; Heart Defects, Congenital; Cardiovascular Abnormalities	Cardiovascular Diseases; Heart Diseases; Splenic Diseases; Lymphatic Diseases; Abnormalities, Multiple; Congenital Abnormalities