Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2015 by University of Alberta
Information provided by (Responsible Party):
Lindsay Ryerson, University of Alberta
ClinicalTrials.gov Identifier:
First received: May 2, 2012
Last updated: June 22, 2015
Last verified: June 2015
Infants with heterotaxy syndrome (HS) are born with an abnormal arrangement of organs along the right-left body axis. Abnormalities of intestinal rotation and fixation are commonly associated with HS. Malrotation is the most worrisome intestinal rotation abnormality (IRA). Advances in cardiac surgery have improved HS mortality such that there is increasing attention to IRA and their management. The objective of this research project is to prospectively observe a cohort of infants with HS and IRA and evaluate their long term outcomes. Specifically, the investigators would like to determine what is the natural history of asymptomatic IRA in patients with HS and what is the morbidity and mortality secondary to an elective Ladd procedure for asymptomatic IRA in a population with HS? The investigators plan a prospective, multi-center, observational study to follow this complicated group of patients. This will be a web-based database collected from major cardiac tertiary care centers in both Canada and the United States. Patients with HS will be recruited by their primary site and clinical data will be collected by their primary site prospectively throughout childhood until they are at least five years of age. This patient population will be followed by their own clinical care givers; this is not an interventional study. No additional clinic visits will be required and the patients will not have to be contacted. Patient medical records will be accessed by a member of the study team at the primary site at least once per year or more frequently if interventions are required or complications develop.

Heterotaxy Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study

Resource links provided by NLM:

Further study details as provided by University of Alberta:

Primary Outcome Measures:
  • Midgut volvulus [ Time Frame: First year of life ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Morbidity secondary to a prophylactic Ladd procedure [ Time Frame: Post Ladd procedure ] [ Designated as safety issue: Yes ]
  • Mortality secondary to a prophylactic Ladd procedure [ Time Frame: Within one month of Ladd procedure ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 50
Study Start Date: March 2012
Estimated Study Completion Date: March 2017
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Infants with heterotaxy syndrome


Ages Eligible for Study:   up to 6 Months
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All infants with heteterotaxy syndrome whose families provide written informed consent.

Inclusion Criteria:

  • All infants less than or equal to six months of age with a new diagnosis of heterotaxy syndrome

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01591928

Contact: Lindsay Ryerson, MD 780 407 3396 ryerson@ualberta.ca

Canada, Alberta
Stollery Children's Hospital Recruiting
Edmonton, Alberta, Canada, T6G 2B7
Contact: Lindsay Ryerson, MD    780 407 3396    ryerson@ualberta.ca   
Principal Investigator: Lindsay Ryerson, MD         
Sponsors and Collaborators
University of Alberta
Principal Investigator: Lindsay Ryerson, MD University of Alberta
  More Information

No publications provided

Responsible Party: Lindsay Ryerson, Assistant Professor, University of Alberta
ClinicalTrials.gov Identifier: NCT01591928     History of Changes
Other Study ID Numbers: 2012-LR-01 
Study First Received: May 2, 2012
Last Updated: June 22, 2015
Health Authority: Canada: Ethics Review Committee

Keywords provided by University of Alberta:
Congenital heart disease
Heterotaxy syndrome
Intestinal malrotation

Additional relevant MeSH terms:
Heterotaxy Syndrome
Abnormalities, Multiple
Cardiovascular Abnormalities
Cardiovascular Diseases
Congenital Abnormalities
Heart Defects, Congenital
Heart Diseases
Lymphatic Diseases
Pathologic Processes
Splenic Diseases

ClinicalTrials.gov processed this record on February 11, 2016