Caffeine and Sodium Citrate Ingestion
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ClinicalTrials.gov Identifier: NCT01591226 |
Recruitment Status
:
Completed
First Posted
: May 3, 2012
Last Update Posted
: November 22, 2016
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A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.
The aim of the study is to investigate whether caffeine or sodium citrate ingestion could enhance performance in spinal cord injured wheelchair athletes. It is a double blind, placebo controlled and randomized study.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Dietary Supplements Heart Rate/Drug Effects Lactic Acid/Metabolism Physical Education and Training/Methods Wheelchairs | Dietary Supplement: Caffeine Dietary Supplement: Sodium Citrate Dietary Supplement: Mannitol Dietary Supplement: Sodium Chloride | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 9 participants |
Allocation: | Randomized |
Intervention Model: | Factorial Assignment |
Masking: | Triple (Participant, Care Provider, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Effects of Caffeine and Sodium Citrate Ingestion in 1500m Wheelchair Racing Athletes |
Study Start Date : | February 2012 |
Actual Primary Completion Date : | September 2012 |
Actual Study Completion Date : | September 2012 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Caffeine
6mg per kg bodyweight ingested 60min before test
|
Dietary Supplement: Caffeine
gelatine capsule 6mg/kg bodyweight 60min prior test
Dietary Supplement: Sodium Chloride
sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test
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Placebo Comparator: Placebo
Sodium chloride and mannitol as placebo are ingested by the athlete
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Dietary Supplement: Mannitol
gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test
Dietary Supplement: Sodium Chloride
sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test
|
Active Comparator: Sodium Citrate
sodium citrate diluted in 7dl water, ingestion 120 to 90min prior test
|
Dietary Supplement: Sodium Citrate
0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test
Dietary Supplement: Mannitol
gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test
|
Active Comparator: Caffeine and Sodium Citrate
sodium citrate 120-90min prior test capsules:60min prior test
|
Dietary Supplement: Caffeine
gelatine capsule 6mg/kg bodyweight 60min prior test
Dietary Supplement: Sodium Citrate
0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test
|
- Time [ Time Frame: 3 weeks ]Time to complete 1500m
- Heart Rate [ Time Frame: during study phase of 3 week (4 tests) ]Heart Rate measured from 2min before the test until 5min after the 1500m-test.
- Lactate Concentration [ Time Frame: during the 3 weeks study phase ]1min before starting the warm up, 15s after the end of the warm up, 15s after completing the test, 2min/4min/6min/8min/10min after the test
- blood pH, sodium concentration and plasma bicarbonate [ Time Frame: during the 3 weeks of study phase ]1min before starting with the ingestion of the fluid, immediately before starting the warm up, just immediately before starting the 1500m test.
- Oxygen Consumption [ Time Frame: during 3 weeks of study phase ]oxygen consumption (VO2(ml/min/kg), VCO2(ml/min), RER (VCO2/VO2)) starting of the measurement is 2min before the start of the 1500m and ends 2min after having completed the 1500m
- rating of gastrointestinal stress [ Time Frame: during the 3 weeks of study phase ]1min before starting to drink the fluid, 2min before starting with the warm up, 2min before the test and 2min after having completed the 1500m
- Rating of Perceived Exertion (RPE) [ Time Frame: during the 3 weeks of study phase ]15s after the end of the warm up, 15s after having completed the 1500m

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Ages Eligible for Study: | 18 Years to 55 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- wheelchair athletes
- national team
- category T53 and T54
Exclusion Criteria:
- medicated
- pregnant (for women)
- cardiovascular and respiratory diseases

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01591226
Switzerland | |
Swiss Paraplegic Centre | |
Nottwil, Lucerne, Switzerland, 6207 |
Principal Investigator: | Claudio Perret, Dr. sc. nat. | Swiss Paraplegic Centre Nottwil |
Responsible Party: | Swiss Paraplegic Centre Nottwil |
ClinicalTrials.gov Identifier: | NCT01591226 History of Changes |
Other Study ID Numbers: |
2012-02 |
First Posted: | May 3, 2012 Key Record Dates |
Last Update Posted: | November 22, 2016 |
Last Verified: | November 2016 |
Keywords provided by Swiss Paraplegic Centre Nottwil:
caffeine sodium citrate exercise performance wheelchair athletes 1500m |
Additional relevant MeSH terms:
Citric Acid Caffeine Mannitol Anticoagulants Calcium Chelating Agents Chelating Agents Sequestering Agents Molecular Mechanisms of Pharmacological Action Central Nervous System Stimulants Physiological Effects of Drugs |
Phosphodiesterase Inhibitors Enzyme Inhibitors Purinergic P1 Receptor Antagonists Purinergic Antagonists Purinergic Agents Neurotransmitter Agents Diuretics, Osmotic Diuretics Natriuretic Agents |