ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
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ClinicalTrials.gov Identifier: NCT01590862 |
Recruitment Status
:
Recruiting
First Posted
: May 3, 2012
Last Update Posted
: November 1, 2016
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Condition or disease |
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Obsessive Compulsive Disorder Major Depressive Disorder |

Study Type : | Observational |
Estimated Enrollment : | 60 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators |
Study Start Date : | June 2012 |
Estimated Primary Completion Date : | December 2017 |
Estimated Study Completion Date : | December 2017 |

Group/Cohort |
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Deep Brain Stimulation Effects on Reward Motivation
We will assess changes in Reward Motivation behavior with Deep Brain Stimulation on and off.
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Patients with MDD or OCD
Patients with MDD or OCD who do not have a deep brain stimulator.
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- Effort Expenditure for Rewards Task (EEfRT) [ Time Frame: 2 hours ]The EEfRT is a multi-trial computer-based task that assess an individual's willingness to expend effort for the chance to earn monetary rewards. We will assess whether stimulation of the Ventral Capsule/Ventral Striatum has an effect on behavior by executing this task with the DBS system on and off.
- Reward learning (clock task) [ Time Frame: 2 hours ]This task is an additional reward task that assesses reward learning. We will assess whether stimulation of the Ventral Capsule/Ventral Striatum has an effect on behavior by executing this task with the DBS system on and off.

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Ages Eligible for Study: | 18 Years to 70 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
DBS Patients:
Inclusion Criteria:
- Deep brain stimulator implantation performed at least three months prior to study
Exclusion Criteria:
- Subjects unable to visualize stimulus objects with correction
- Dementia or other known cognitive deficit
Psychiatric Patients:
Inclusion Criteria:
- Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
- Normal or corrected-to normal vision and hearing
- Current diagnosis of MDD or OCD
Exclusion Criteria for Patients:
- Clinical history of bipolar disorder
- Current or past psychotic disorder
- Gross structural brain damage
- Cognitive impairment that would affect a participant's ability to give informed consent
- Current substance abuse, or abuse within the past 3 months
- Clinical history of severe personality disorder
- Imminent risk of suicide or an inability to control suicide attempts
- Evidence of dementia or other significant cognitive impairment on neuropsychological evaluation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01590862
Contact: Aishwarya Gosai, BA | 617-724-0244 | agosai@partners.org |
United States, Massachusetts | |
Massachusetts General Hospital | Recruiting |
Boston, Massachusetts, United States, 02114 | |
Contact: Darin D Dougherty, MD ddougherty@partners.org | |
Principal Investigator: Darin D Dougherty, MD | |
Massachusetts General Hospital | Not yet recruiting |
Charlestown, Massachusetts, United States, 02129 | |
Contact: Anna L Gilmour, BA 617-726-9281 agilmour@partners.org | |
Principal Investigator: Darin D Daugherty, MD |
Responsible Party: | Darin Dougherty, Associate Professor of Psychiatry, Massachusetts General Hospital |
ClinicalTrials.gov Identifier: | NCT01590862 History of Changes |
Other Study ID Numbers: |
2011P002821 |
First Posted: | May 3, 2012 Key Record Dates |
Last Update Posted: | November 1, 2016 |
Last Verified: | October 2016 |
Keywords provided by Darin Dougherty, Massachusetts General Hospital:
Obesessive Compulsive Disorder Major Depressive Disorder Deep Brain Stimulation |
Additional relevant MeSH terms:
Disease Depressive Disorder Depression Depressive Disorder, Major Compulsive Personality Disorder Obsessive-Compulsive Disorder |
Pathologic Processes Mood Disorders Mental Disorders Behavioral Symptoms Personality Disorders Anxiety Disorders |