The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects (EXAP)
Recruitment status was Recruiting
The purpose of this study is to
- Determine blood peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers.
- Evaluate the effect of exogenous apelin infusion on exercise performance in healthy volunteers and patients with idiopathic pulmonary arterial hypertension.
Idiopathic Pulmonary Arterial Hypertension
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:||The Apelin-APJ System in Idiopathic Pulmonary Arterial Hypertension and Healthy Volunteers; Tissue Location and Cardiopulmonary Response.|
- Effect of Apelin infusion on cardiopulmonary performance in healthy volunteers and patient with idiopathic pulmonary hypertension [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
Characterise circulating peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers.
Assess the effect of exogenous apelin infusion on exercise performance in healthy volunteers and patients with idiopathic pulmonary arterial hypertension.
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||September 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Subject will perform cardiopulmonary exercise testing and receive (Pyr1)apelin-13 intravenously.
(Pyr1)apelin-13 will be infused at 30 nanomol/min intravenously. This dose has been used in healthy volunteer and patients groups
Placebo Comparator: Control
Subject will take cardiopulmonary exercise testing with receive placebo
Please refer to this study by its ClinicalTrials.gov identifier: NCT01590108
|Contact: Gareth D Barnes, MBChB||07967 621 firstname.lastname@example.org|
|Hammersmith Hospital, Imperial College London||Not yet recruiting|
|London, United Kingdom, W12 0HS|
|Contact: Gareth D Barnes, MBChB 07967 621 980 email@example.com|
|Imperial College Healthcare NHS Trust||Recruiting|
|London, United Kingdom, w12 0NN|
|Contact: Gareth D Barnes, MBChB firstname.lastname@example.org|
|Contact: Akaphot Thongmee, MD email@example.com|
|Sub-Investigator: Gareth D Barnes, MBChB|
|Principal Investigator: Luke Howard, PhD|
|Sub-Investigator: Akaphot Thongmee, MD|
|Principal Investigator:||Luke Sebastian Howard, DPhil||Imperial College NHS Trust|
|Study Director:||Gareth D Barnes, MBChB||Imperial College NHS trust|