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Identification the Expression of Sox2 in Colorectal Cancer Tissues

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ClinicalTrials.gov Identifier: NCT01589900
Recruitment Status : Completed
First Posted : May 2, 2012
Last Update Posted : May 3, 2012
Information provided by (Responsible Party):
Lixiao Xu, Sun Yat-sen University

Brief Summary:
Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.

Condition or disease
Colorectal Cancer

Detailed Description:
In our study, we examined Sox2 expression in archived human colon cancer tissues and found that its Sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.

Study Type : Observational
Actual Enrollment : 136 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Role of Sox2 in Tumor Genesis and Migration in Colorectal Cancer
Study Start Date : January 2005
Primary Completion Date : December 2006
Study Completion Date : March 2012

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Ages Eligible for Study:   24 Years to 79 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All rchived 136 tissues were obtained and pathologically confirmed from patients who underwent surgical resections between 2005 and 2006 at the Cancer Center of Sun Yat-sen University (Guangzhou, Guangdong, P. R. China)). The patients from whom the samples were derived underwent curative resection between 2005 and 2006. Tumor differentiation was characterized according to WHO classification, while the surgical pathologic stage was analyzed according to the TNM classification system of the International Union against Cancer. All samples were anonymously coded in accordance with local ethical guidelines.

Inclusion Criteria:

  • Clinical diagnosis of colorectal cancer

Exclusion Criteria:

  • Clinical diagnosis characteristics not exactly described in the patients information

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01589900

Sponsors and Collaborators
Sun Yat-sen University
Principal Investigator: Yan Zhang, M.D.Ph.D Laboratory of Cancer and Stem Cell Biology School of Life Sciences Sun Yat-sen University

Additional Information:
Responsible Party: Lixiao Xu, Laboratory of Cancer and Stem Cell Biology, Sun Yat-sen University
ClinicalTrials.gov Identifier: NCT01589900     History of Changes
Other Study ID Numbers: SYSU
First Posted: May 2, 2012    Key Record Dates
Last Update Posted: May 3, 2012
Last Verified: May 2012

Keywords provided by Lixiao Xu, Sun Yat-sen University:
colorectal cancer

Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases