Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes
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ClinicalTrials.gov Identifier: NCT01589458 |
Recruitment Status :
Completed
First Posted : May 2, 2012
Last Update Posted : May 2, 2012
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Dental Caries | Drug: Toothpaste | Phase 1 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 12 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Prevention |
Official Title: | Fluoride Availability in Saliva After Use of NaF or MFP Toothpastes |
Study Start Date : | August 2011 |
Actual Primary Completion Date : | February 2012 |
Actual Study Completion Date : | March 2012 |

Arm | Intervention/treatment |
---|---|
Placebo Comparator: Non-fluoride toothpaste |
Drug: Toothpaste
1-min brushing with 1 g of the assigned toothpaste followed by a 10 mL purified water rinse |
Experimental: NaF/SiO2 toothpaste |
Drug: Toothpaste
1-min brushing with 1 g of the assigned toothpaste followed by a 10 mL purified water rinse |
Experimental: MFP/CaCO3 toothpaste |
Drug: Toothpaste
1-min brushing with 1 g of the assigned toothpaste followed by a 10 mL purified water rinse |
- Area under the curve of salivary fluoride concentration versus time after brushing with fluoride toothpastes [ Time Frame: 60 minutes ]
- Percentage of MFP hydrolyzed in saliva as a function of time [ Time Frame: 60 minutes ]

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Ages Eligible for Study: | 18 Years to 35 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Good general health
- Good oral health
- Normal salivary flow rate
Exclusion Criteria:
- Use of systemic drugs that reduce salivary flow rate

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01589458
Brazil | |
Piracicaba Dental School, University of Campinas | |
Piracicaba, São Paulo, Brazil, 13414903 |
Principal Investigator: | Livia MA Tenuta, PhD | Piracicaba Dental School, University of Campinas |
Responsible Party: | Livia Maria Andaló Tenuta, Assistant Professor, Biochemistry and Cariology, University of Campinas, Brazil |
ClinicalTrials.gov Identifier: | NCT01589458 |
Other Study ID Numbers: |
FOPBioq003 |
First Posted: | May 2, 2012 Key Record Dates |
Last Update Posted: | May 2, 2012 |
Last Verified: | April 2012 |
toothpastes saliva dental caries fluoride |
Dental Caries Tooth Demineralization Tooth Diseases Stomatognathic Diseases |