Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Kyung Mook Choi, Korea University
ClinicalTrials.gov Identifier:
NCT01589224
First received: April 24, 2012
Last updated: October 12, 2015
Last verified: April 2012
  Purpose
Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.

Condition
Atherosclerosis
Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Korea University:

Primary Outcome Measures:
  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT [ Time Frame: 3month ] [ Designated as safety issue: No ]
    to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score


Secondary Outcome Measures:
  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT [ Time Frame: 3months ] [ Designated as safety issue: No ]
    to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score

  • the correlation of various inflammatory markers with coronary atherosclerosis [ Time Frame: 3months ] [ Designated as safety issue: No ]

Enrollment: 150
Study Start Date: May 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Healthy people

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Apparently healthy people who underwent medical routine check up in Korea Helath Promotion Center.
Criteria

Inclusion Criteria:

  • Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center.
  • age > 20 years

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • Diabetes
  • Stage 2 hypertension
  • Severe renal or hepatic disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01589224

Locations
Korea, Republic of
korea University Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
  More Information

Responsible Party: Kyung Mook Choi, Professor, Korea University
ClinicalTrials.gov Identifier: NCT01589224     History of Changes
Other Study ID Numbers: KoreaHealth_MDCT 
Study First Received: April 24, 2012
Last Updated: October 12, 2015
Health Authority: South Korea: Institutional Review Board

Additional relevant MeSH terms:
Metabolic Syndrome X
Atherosclerosis
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on July 24, 2016