Identification of Molecular Biomarkers to Stratify Patients With Refractory Asthma
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The purpose of this study is to learn more about asthma in people who are not well-controlled with current asthma medication (refractory asthma). The investigators will compare data from refractory asthmatic patients here at National Jewish Health to mild asthmatics subjects and to people without asthma. Study experiments involve looking at samples from all 3 groups and comparing them at a molecular level. These laboratory experiments may help identify subtypes of refractory asthmatics that require different treatments.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
We are looking for mild non-smoking asthmatic adults who are well-controlled with their asthma therapy (non-refractory asthmatics).
Able to receive Informed Consent
At least 18 years of age
ICS < 880 mcg (FP equivalents)
No more than 1 oral steroid bursts in previous 12 months
Less that 3 urgent care visit in previous 12 months
No deterioration with <=25% decrease in steroids
No near fatal asthma event
Current smoker, smoking within the past year or pack/year history >10 years
Respiratory infection within past 6 weeks
Antibiotics within the past 6 weeks
Active lung disease other than asthma
Cancer within past 5 years (excluding basal cell skin cancer)
Active or chronic infection
Hematological or autoimmune disease
Unable to safely undergo bronchoscopy as determined by doctor or study doctor