Studying Gene Expression and Location in Samples From Patients With Brain Tumors

This study is ongoing, but not recruiting participants.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: April 24, 2012
Last updated: May 6, 2015
Last verified: May 2015

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

Condition Intervention
Brain and Central Nervous System Tumors
Genetic: gene expression analysis
Genetic: genetic linkage analysis
Genetic: microarray analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Expression and Subcellular Localization of NEIL3 in Tumors

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: April 2012
Estimated Primary Completion Date: January 2100 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed with brain tumors


  • Tissue microarrays (TMA) samples from the Biopathology Core
  • Samples from patients diagnosed with brain tumors

    • Progenitor, or blast, cell origin


  • Not specified


  • Not specified
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Please refer to this study by its identifier: NCT01585389

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Heithem M. El-Hodiri, PhD Nationwide Children's Hospital
  More Information

Additional Information:
No publications provided

Responsible Party: Children's Oncology Group Identifier: NCT01585389     History of Changes
Other Study ID Numbers: ABTR12B3  COG-ABTR12B3  ABTR12B3  CDR0000732178  NCI-2012-00731 
Study First Received: April 24, 2012
Last Updated: May 6, 2015
Health Authority: United States: Federal Government

Keywords provided by Children's Oncology Group:
adult brain tumor
childhood brain tumor

Additional relevant MeSH terms:
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Nervous System Diseases processed this record on February 04, 2016