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Studying Gene Expression and Location in Samples From Patients With Brain Tumors

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: April 24, 2012
Last updated: May 17, 2016
Last verified: May 2016

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

Condition Intervention
Brain and Central Nervous System Tumors Genetic: gene expression analysis Genetic: genetic linkage analysis Genetic: microarray analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Expression and Subcellular Localization of NEIL3 in Tumors

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation

Estimated Enrollment: 10
Study Start Date: April 2012
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed with brain tumors


  • Tissue microarrays (TMA) samples from the Biopathology Core
  • Samples from patients diagnosed with brain tumors

    • Progenitor, or blast, cell origin


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01585389

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Heithem M. El-Hodiri, PhD Nationwide Children's Hospital
  More Information

Responsible Party: Children's Oncology Group Identifier: NCT01585389     History of Changes
Other Study ID Numbers: ABTR12B3
COG-ABTR12B3 ( Other Identifier: Children's Oncology Group )
ABTR12B3 ( Other Identifier: Children's Oncology Group )
CDR0000732178 ( Other Identifier: Clinical )
NCI-2012-00731 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
Study First Received: April 24, 2012
Last Updated: May 17, 2016

Keywords provided by Children's Oncology Group:
adult brain tumor
childhood brain tumor

Additional relevant MeSH terms:
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms by Site
Nervous System Diseases processed this record on August 18, 2017