Studying Gene Expression and Location in Samples From Patients With Brain Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.
PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.
Brain and Central Nervous System Tumors
Genetic: gene expression analysis
Genetic: genetic linkage analysis
Genetic: microarray analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Expression and Subcellular Localization of NEIL3 in Tumors|
- Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation
|Study Start Date:||April 2012|
|Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
- To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.
OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01585389
|Principal Investigator:||Heithem M. El-Hodiri, PhD||Nationwide Children's Hospital|