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Studying Gene Expression and Location in Samples From Patients With Brain Tumors

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01585389
First Posted: April 25, 2012
Last Update Posted: May 18, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group
  Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.


Condition Intervention
Brain and Central Nervous System Tumors Genetic: gene expression analysis Genetic: genetic linkage analysis Genetic: microarray analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Expression and Subcellular Localization of NEIL3 in Tumors

Resource links provided by NLM:


Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation

Estimated Enrollment: 10
Study Start Date: April 2012
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed with brain tumors
Criteria

DISEASE CHARACTERISTICS:

  • Tissue microarrays (TMA) samples from the Biopathology Core
  • Samples from patients diagnosed with brain tumors

    • Progenitor, or blast, cell origin

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01585389


Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Investigators
Principal Investigator: Heithem M. El-Hodiri, PhD Nationwide Children's Hospital
  More Information

Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT01585389     History of Changes
Other Study ID Numbers: ABTR12B3
COG-ABTR12B3 ( Other Identifier: Children's Oncology Group )
ABTR12B3 ( Other Identifier: Children's Oncology Group )
CDR0000732178 ( Other Identifier: Clinical Trials.gov )
NCI-2012-00731 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
First Submitted: April 24, 2012
First Posted: April 25, 2012
Last Update Posted: May 18, 2016
Last Verified: May 2016

Keywords provided by Children's Oncology Group:
adult brain tumor
childhood brain tumor

Additional relevant MeSH terms:
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms by Site
Neoplasms
Nervous System Diseases