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Sleep Duration Required to Restore Performance During Chronic Sleep Restriction

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01581125
First Posted: April 19, 2012
Last Update Posted: July 18, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Elizabeth B. Klerman, Brigham and Women's Hospital
  Purpose
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase.

Condition Intervention
Sleep Sleep Deprivation Insufficient Sleep Syndrome Behavioral: Sleep:wake 1 Behavioral: Sleep:wake 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Sleep Duration Required to Restore Performance During Chronic Sleep Restriction

Further study details as provided by Elizabeth B. Klerman, Brigham and Women's Hospital:

Primary Outcome Measures:
  • Psychomotor Vigilance Task (PVT) performance [ Time Frame: PVT during waking for arms 1 and 2 during the 32-day inpatient portion of the protocol ]
    PVT metrics are reaction time. It is measured when the participants are awake during the inpatient portion of the protocol.


Enrollment: 19
Study Start Date: April 2012
Study Completion Date: June 2016
Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sleep:wake 2
Sleep and wake durations for arm 2 for inpatient portion of protocol. .There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 1.
Behavioral: Sleep:wake 2
Sleep and Wake durations for arm2
Experimental: Sleep:wake 1
Sleep and wake durations for arm 1 of the inpatient portion of the protocol. There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 2.
Behavioral: Sleep:wake 1
Sleep and Wake durations for arm 1

Detailed Description:
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase. Inpatient sleep and performance data will be collected from healthy volunteers.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy

Exclusion Criteria:

  • Prescription medications
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01581125


Locations
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Brigham and Women's Hospital
Investigators
Principal Investigator: Elizabeth B Klerman, MD PhD Brigham and Women's Hospital
  More Information

Responsible Party: Elizabeth B. Klerman, Associate Professor, Associate Physician, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT01581125     History of Changes
Other Study ID Numbers: NIH R01 HL114088-01
First Submitted: March 22, 2012
First Posted: April 19, 2012
Last Update Posted: July 18, 2016
Last Verified: July 2016

Keywords provided by Elizabeth B. Klerman, Brigham and Women's Hospital:
Inpatients
Health Normalcy
circadian rhythm

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders


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