Effects of Berries on Post-meal Blood Sugar (SOMA)
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|ClinicalTrials.gov Identifier: NCT01580150|
Recruitment Status : Completed
First Posted : April 18, 2012
Last Update Posted : April 18, 2012
|Condition or disease||Intervention/treatment||Phase|
|Blood Glucose, Postprandial Blood Insulin, Postprandial Hyperglycemia||Other: Berries Other: No berries||Not Applicable|
Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.
The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:
- Studies 1-2: white wheat bread (starch) is consumed with several berry species
- Study 3: white wheat bread or rye bread is consumed with a mixture of berries
- Study 4: sugar (sucrose) is consumed with berries and berry nectars
- Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch|
|Study Start Date :||November 2009|
|Actual Primary Completion Date :||January 2012|
|Actual Study Completion Date :||January 2012|
Experimental: Berry meal
Carbohydrate meals with berries
Meals containing starch (bread) or sucrose are consumed with berries (150 g) or berry nectars (300 mL).
Active Comparator: Reference meal
Carbohydrate meals without berries
Other: No berries
Meals containing starch (bread) or sucrose are consumed without berries.
- Plasma glucose [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]
- Plasma insulin [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]
- Plasma free fatty acids [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01580150
|University of Eastern Finland|
|Kuopio, Finland, FI-70211|
|Principal Investigator:||Riitta Törrönen, Dr||Senior Scientist|