Detection of Immune Changes as a Result of Surgical Trauma in Human Subject
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Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study to characterize the cellular and molecular mechanisms immune response to surgical trauma. Additionally, detailed information about patients' recovery profile will be recorded over a period of 6 weeks, with the eventual goal of linking immune responses to recovery profiles.
Mass cytometry of immune signaling events [ Time Frame: Blood samples for mass cytometry will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op. ]
The primary molecular outcome is the fold change in phosphorylation of signaling proteins.
Secondary Outcome Measures
Surgical Recovery Scale (SRS) [ Time Frame: Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks. ]
The surgical recovery scale is a validated questionnaire yielding a numerical score and assessing postoperative recovery.
Western Ontario and McMaster Universities Arthritis Index (WOMAC) [ Time Frame: Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks. ]
Western Ontario and McMaster Universities Arthritis Index is a validated questionnaires yielding a numerical score and assessing functional status and pain in patients suffering from osteoarthritis of the hip.
Plasma cytokines [ Time Frame: Blood samples will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op. ]
The plasma concentration of plasma cytokines and chemokines will be measured with aid of a large protein array.
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Ages Eligible for Study:
18 Years to 90 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients undergoing primary hip replacement.
18 - 90
Planning to undergo hip surgery
Fluent in English
Willing and able to sign informed consent and HIPAA authorization
Any systemic disease that might compromise the immune system
Diagnosis of cancer within the last 5 years
Psychiatric, immunological, and neurological conditions that would interfere with the collection and interpretation of study data
Any other conditions that, in the opinion of the investigators, may compromise a participant's safety or the integrity of the study