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Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men (Meat-Milk Study) (Meat-Milk)

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ClinicalTrials.gov Identifier: NCT01578590
Recruitment Status : Completed
First Posted : April 17, 2012
Last Update Posted : December 2, 2014
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

Rationale: The consumption of dietary protein immediately after exercise is necessary to maximally stimulate muscle protein synthesis rates (24, 37). Recent work suggests that the type of protein consumed (e.g., animal vs. plant-derived proteins) during post-exercise recovery can affect the amplitude of acute increases in muscle protein synthesis rates (25, 31). Specifically, consumption of bovine milk proteins immediately after a single bout of resistance exercise stimulates muscle protein synthesis rates greater than consumption of an isonitrogenous soy-protein beverage (31, 37). Importantly, consumption of milk promotes greater hypertrophy than soy after resistance training (10). Thus, it is generally assumed that the acute muscle protein synthetic response predicts long-term training outcomes, such as hypertrophy. Currently, a great amount of work has been carried out to study the effects of consuming milk proteins on muscle protein synthesis rates after resistance exercise (5, 7, 26, 32). However, very little is known about the effects of other types of high-quality animal proteins, such as beef, on stimulating post-exercise muscle protein synthesis rates. Further describing the muscle protein synthetic response after consumption of other types of high-quality animal proteins will provide valuable information for individuals with milk allergies, lactose intolerance, or simply a strong dislike of dairy products.

Objective: To investigate whether the in vivo post-resistance exercise muscle protein synthetic response is augmented when minced beef is ingested as compared to an isonitrogenous-matched milk protein beverage in healthy young men.

Study design: Crossover, randomized

Study population: 12 healthy young males (18-35 y).

Intervention: Subjects will perform resistance exercise and consume either a piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage on two separate test days. In addition, continuous intravenous tracer infusions will be applied, with plasma and muscle samples collected. A two week 'wash-out' period will be included between trials.

Main study parameters/endpoints Primary endpoint: Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR). Secondary endpoints: Rate of protein digestion and absorption and whole body protein balance.


Condition or disease Intervention/treatment
Skeletal Muscle Hypertrophy Dietary Supplement: Lean minced meat (beef)

  Show Detailed Description

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men
Study Start Date : May 2012
Primary Completion Date : August 2012
Study Completion Date : August 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Subjects will consume lean minced meat
Subjects will perform resistance exercise and consume a piece of meat (135 grams, 35 g of protein)
Dietary Supplement: Lean minced meat (beef)
A piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage
Other Names:
  • Meat
  • Milk
Active Comparator: Subjects will consume a milk beverage
Subjects will perform resistance exercise and consume a milk protein beverage
Dietary Supplement: Lean minced meat (beef)
A piece of meat (135 grams, 35 g of protein) or an isonitrogenous-matched milk protein beverage
Other Names:
  • Meat
  • Milk


Outcome Measures

Primary Outcome Measures :
  1. Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR) [ Time Frame: 1 day ]

Secondary Outcome Measures :
  1. Rate of protein digestion and absorption and whole body protein balance [ Time Frame: 1 day ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI < 25 kg/m2

Exclusion Criteria:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Vegetarians
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Previous participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01578590


Locations
Netherlands
University of Maastricht
Maastricht, Limburg, Netherlands, 6229 ER
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc JC van Loon, Prof. Dr. Maastricht University
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Stefan Gorissen, Principal Investigator, Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01578590     History of Changes
Other Study ID Numbers: METC 11-3-088
First Posted: April 17, 2012    Key Record Dates
Last Update Posted: December 2, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
Hypertrophy
Pathological Conditions, Anatomical