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Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness

This study has been completed.
Information provided by (Responsible Party):
University of Texas at Austin Identifier:
First received: April 10, 2012
Last updated: February 10, 2014
Last verified: February 2014
Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.

Condition Intervention
Stage-1 Hypertension
Dietary Supplement: Non-fat dairy
Dietary Supplement: Add 4 servings fruit

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness

Resource links provided by NLM:

Further study details as provided by University of Texas at Austin:

Primary Outcome Measures:
  • Seated blood pressure [ Time Frame: 4 weeks ]

Secondary Outcome Measures:
  • 24-hour ambulatory blood pressure [ Time Frame: 4 weeks ]
  • Carotid arterial compliance [ Time Frame: 4 weeks ]
  • Arterial stiffness [ Time Frame: 4 weeks ]
  • Flow mediated dilation [ Time Frame: 4 weeks ]

Enrollment: 49
Study Start Date: January 2012
Study Completion Date: November 2013
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Dairy
Add 4 daily servings of non-fat dairy to diet for a period of 4 weeks
Dietary Supplement: Non-fat dairy
Add 4 daily servings per day of non-fat dairy (yogurt, milk, cheese) for a period of 4 weeks
Active Comparator: Fruit
Add 4 daily servings of fruit to diet, remove all dairy from diet for a period of 4 weeks
Dietary Supplement: Add 4 servings fruit
Add 4 daily servings of fruit (fruit cup, apple sauce, orange juice) and remove all dairy for a period for 4 weeks


Ages Eligible for Study:   35 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Prehypertension or stage-1 hypertension

Exclusion Criteria:

  • Consume > 3 servings of dairy or fruit per day
  • Strenuous physical activity > 3 time per week
  • Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
  • Taking cardiovascular-acting drugs
  • Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
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Please refer to this study by its identifier: NCT01577030

United States, Texas
The University of Texas at Austin, Cardiovascular Aging Research Laboratory
Austin, Texas, United States, 78712
Sponsors and Collaborators
University of Texas at Austin
Principal Investigator: Hirofumi Tanaka, PhD University of Texas at Austin
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University of Texas at Austin Identifier: NCT01577030     History of Changes
Other Study ID Numbers: LH002
Study First Received: April 10, 2012
Last Updated: February 10, 2014

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Antihypertensive Agents processed this record on May 25, 2017