The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
As both medications i.e. CC and letrozole have been shown to be effective in inducing ovulation in PCOS patients, this study was performed in order to evaluate which regime (whether CC or letrozole) is the best to be used as the first line treatment for PCOS patients with infertility for local population. The best regime will therefore could be included in the protocol of management of infertility patients with PCOS so that the quality of patients' care could be improved.
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Study On The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)|
- To evaluate the effectiveness of ovulation induction among PCOS patients [ Time Frame: 6 weeks ] [ Designated as safety issue: Yes ]To evaluate the effectiveness of letrozole and clomiphene citrate for induction of ovulation in PCOS patients.
- Number of patients that can ovulate and pregnant [ Time Frame: 6 weeks ] [ Designated as safety issue: Yes ]i. ovulation rate among PCOS patients with letrozole and CC ii. endometrial thickness among patients with letrozole and CC iii. number of pregnancy between letrozole and CC iv. associated factors that can influence the effectiveness of the treatment found in age, body weight, duration of marriage, duration of infertility and types of infertility either primary or secondary among PCOS patients.
|Study Start Date:||May 2008|
|Study Completion Date:||March 2012|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
Group L will be assigned with Letrozole 5 mg on night on day 5 to day 9 of the cycle
Women in group L will be assigned with Letrozole on night at day 5 to day 9 of the cycle
Other Name: Femara (Aromatase Inhibitor)
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