Central Hypothyroidism and Cardiovascular Risk
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of Medica Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4) replacement and cardiovascular risk factors. The hypothesis is that subtle central hypothyroidism is associated with adverse cardiac risk factors, such as body composition and serum lipids, and that improved T4 replacement will eliminate this increased risk, independently of other pituitary hormone replacements.
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Central Hypothyroidism and Cardiovascular Risk Factors|
- cholesterol [ Time Frame: March 2002 - March 2013 ] [ Designated as safety issue: No ]
|Study Start Date:||April 2012|
|Study Completion Date:||March 2013|
|Primary Completion Date:||November 2012 (Final data collection date for primary outcome measure)|
group of patients with hypopituitarism
titration of T4 according to biochemical values
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of Medical Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4) replacement and cardiovascular risk profile. The patient files are recruited among hypopituitary patients treated with growth hormone from the period 1993 to 2008. The trial is a retrospective assessment of data already collected for routine purposes and thus an audit of daily clinical practice. All information on the patients is obtained from the paper and electronic files existing in the department and no new measurements are foreseen.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01574859
|Copenhagen, Denmark, 2100|
|Principal Investigator:||Ulla Feldt-Rasmussen, Professor||Rigshospitalet, Denmark|