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Merck IISP Stewardship Grant for Antibiotic Best Practices

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01573195
First Posted: April 6, 2012
Last Update Posted: December 18, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Wisconsin, Madison
  Purpose
The purpose of this study is to pilot the use of best practices alerts to enhance an antimicrobial stewardship program using the electronic medical record, EPIC.

Condition Phase
Antibiotic Resistant Infection Phase 4

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Implementation of Antimicrobial Stewardship and Decision Support Into the EPIC Electronic Medical Record

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Percentage of best practice alerts(BPA) that were completely accepted, partially accepted, or rejected within 72 hours of issuing the BPA [ Time Frame: One Year ]
    after issuing the BPA for deescalation, the responding healthcare provider will respond in one of the manners above


Secondary Outcome Measures:
  • The number and type of antiinfectives that were administered before and after(11days) the best practice alert is issued. [ Time Frame: One year ]
    The antiinfective use before and after the BPA will be analyzed in detail. The number of antibiotics, percentage decrease(or less likely increase) in antiinfectives in the 3 days before BPA , and 11 days after the BPA will be analyzed. A cost analysis will be performed. Patient outcomes will not be assessed.


Enrollment: 1285
Study Start Date: March 2011
Study Completion Date: April 2012
Primary Completion Date: April 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
All prescribing MDs at UWHC
Observational for accept, reject, or accept with modification of Best Practice Alers

Detailed Description:
The purpose of this study is to pilot the use of best practices to enhance an antimicrobial stewardship program using the electronic medical record, EPIC. Screening information technology tools via SETNET/Safety SUrveyor(Premier) and the electronic anti-infective order form would allow for sufficient medical record review to create best practices alerts for the purpose of appropriate de-escalation of anti-invectives.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
1285 consecutive patients issued BPA for de-escalation of antibiotics in EPIC
Criteria

Inclusion Criteria:

  • Physicians with prescribing privileges at the UWHC

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01573195


Locations
United States, Wisconsin
University of Wisconsin Hospitals and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Barry C Fox, MD University of Wisconsin, Madison
  More Information

Additional Information:
Publications:
Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT01573195     History of Changes
Other Study ID Numbers: 2012-0168 (MSN141105)
Merk Dr Fox ( Other Grant/Funding Number: Proposal #38732 )
First Submitted: May 4, 2011
First Posted: April 6, 2012
Last Update Posted: December 18, 2014
Last Verified: December 2014

Keywords provided by University of Wisconsin, Madison:
deescalation
best practice alert
antimicrobial stewardship