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Merck IISP Stewardship Grant for Antibiotic Best Practices

This study has been completed.
Information provided by (Responsible Party):
University of Wisconsin, Madison Identifier:
First received: May 4, 2011
Last updated: December 16, 2014
Last verified: December 2014
The purpose of this study is to pilot the use of best practices alerts to enhance an antimicrobial stewardship program using the electronic medical record, EPIC.

Condition Phase
Antibiotic Resistant Infection
Phase 4

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Implementation of Antimicrobial Stewardship and Decision Support Into the EPIC Electronic Medical Record

Resource links provided by NLM:

Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Percentage of best practice alerts(BPA) that were completely accepted, partially accepted, or rejected within 72 hours of issuing the BPA [ Time Frame: One Year ]
    after issuing the BPA for deescalation, the responding healthcare provider will respond in one of the manners above

Secondary Outcome Measures:
  • The number and type of antiinfectives that were administered before and after(11days) the best practice alert is issued. [ Time Frame: One year ]
    The antiinfective use before and after the BPA will be analyzed in detail. The number of antibiotics, percentage decrease(or less likely increase) in antiinfectives in the 3 days before BPA , and 11 days after the BPA will be analyzed. A cost analysis will be performed. Patient outcomes will not be assessed.

Enrollment: 1285
Study Start Date: March 2011
Study Completion Date: April 2012
Primary Completion Date: April 2012 (Final data collection date for primary outcome measure)
All prescribing MDs at UWHC
Observational for accept, reject, or accept with modification of Best Practice Alers

Detailed Description:
The purpose of this study is to pilot the use of best practices to enhance an antimicrobial stewardship program using the electronic medical record, EPIC. Screening information technology tools via SETNET/Safety SUrveyor(Premier) and the electronic anti-infective order form would allow for sufficient medical record review to create best practices alerts for the purpose of appropriate de-escalation of anti-invectives.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
1285 consecutive patients issued BPA for de-escalation of antibiotics in EPIC

Inclusion Criteria:

  • Physicians with prescribing privileges at the UWHC

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01573195

United States, Wisconsin
University of Wisconsin Hospitals and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Barry C Fox, MD University of Wisconsin, Madison
  More Information

Additional Information:
Responsible Party: University of Wisconsin, Madison Identifier: NCT01573195     History of Changes
Other Study ID Numbers: 2012-0168 (MSN141105)
Merk Dr Fox ( Other Grant/Funding Number: Proposal #38732 )
Study First Received: May 4, 2011
Last Updated: December 16, 2014

Keywords provided by University of Wisconsin, Madison:
best practice alert
antimicrobial stewardship

Additional relevant MeSH terms:
Anti-Infective Agents processed this record on May 25, 2017