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Microvascular Function Assessment in Healthy Subjects (MICROTEC)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Angers Identifier:
First received: April 4, 2012
Last updated: February 11, 2016
Last verified: February 2016
Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2) whether this amplification relies on prostaglandin-sensitive mechanisms. A double-blind randomized placebo-controlled crossover trial is conducted in Angers, France.

Condition Intervention
Physiology of Microvascular Skin Drug: acetylsalicilic acids (Aspirin) Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Basic Science
Official Title: Amélioration Des Techniques d'étude de la Micro-cirulation cutanée Chez Des Sujets Sains

Resource links provided by NLM:

Further study details as provided by University Hospital, Angers:

Primary Outcome Measures:
  • The increase of Laser Doppler Blood Flow after the second current stimulation [ Time Frame: 1 hour ]

Secondary Outcome Measures:
  • The increase of Laser Doppler Blood Flow after the second current stimulation after aspirin administration [ Time Frame: 1 hour ]

Enrollment: 16
Study Start Date: November 2010
Study Completion Date: May 2013
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Aspirin
Drug: acetylsalicilic acids (Aspirin)
single oral dose of 1g.
Other Name: Aspegic 1000mg, sanofi aventis.
Placebo Comparator: Placebo
Drug: Placebo


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age > or equal to 18 years old
  • Healthy subjects

Exclusion Criteria:

  • Aspirin allergy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01572961

University Hospital
Angers, Maine et Loire, France, 49933
Sponsors and Collaborators
University Hospital, Angers
Principal Investigator: Guillaume Mahe, M.D., Ph.D. University hospital of Angers
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University Hospital, Angers Identifier: NCT01572961     History of Changes
Other Study ID Numbers: 2010-10
Study First Received: April 4, 2012
Last Updated: February 11, 2016

Keywords provided by University Hospital, Angers:
Laser Doppler flowmetry, skin, microcirculation

Additional relevant MeSH terms:
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics processed this record on August 18, 2017