Lung Ultrasound in the Evaluation of Pneumothorax Size (LUS-PNXsize)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01572584
Recruitment Status : Completed
First Posted : April 6, 2012
Last Update Posted : December 19, 2013
Information provided by (Responsible Party):
Giovanni Volpicelli, San Luigi Gonzaga Hospital

Brief Summary:


  • Assessment of the percentage of lung collapse is crucial in the therapeutic decision-making of pneumothorax.
  • The methods normally used to this purpose are radiological. Computerized tomography scan (CT) is highly accurate because it allows the exact evaluation of the volume of the air layer. However, in clinical practice assessment of the volume of pneumothorax mainly relies on the measurement of the inter-pleural distance at conventional chest radiography (CXR). This latter method is inaccurate.
  • Lung ultrasound is a new method highly accurate in the first diagnosis of pneumothorax, with a sensitivity superior to CXR and similar to CT in case of traumatic pneumothorax.
  • The scientific community is actually debating about the usefulness of lung ultrasound in the quantification of pneumothorax []. Lung ultrasound can assess the superficial extension of the pneumothorax, but cannot evaluate its volume.


  • Main purpose of the study is to compare measurement of the superficial extension of pneumothorax on the chest wall obtained by lung ultrasound, to the evaluation of the air volume performed by CT in patients with pneumothorax.
  • The main hypothesis of the study is that the cut-off between small (<11% of lung collapse) and large (>11% of lung collapse) pneumothorax can be identified by a lung ultrasound evaluation of the superficial extension of pneumothorax.
  • Second purpose of the study is to compare the accuracies of lung ultrasound and CXR in predicting the volume of pneumothorax assessed by CT.
  • Secondary hypothesis is that lung ultrasound demonstrates greater accuracy in the prediction of volume of pneumothorax and percentage of lung collapse.


  • Patients with a diagnosis of pneumothorax confirmed at CT are prospectively enrolled and submitted to lung ultrasound within 20 min from the CT study.
  • Different locations of the sonographic "lung point" on the chest wall (i.e. the point on the chest wall where the sonographic pattern of the normally aerated lung alternates with the pathologic sonographic pattern of pneumothorax) are compared with different volumes of pneumothorax measured by CT.

Condition or disease

Study Type : Observational
Actual Enrollment : 115 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Accuracy of Lung Ultrasound in the Prediction of Pneumothorax Volume Assessed by CT Scan
Study Start Date : December 2011
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. The ultrasound lung point on the thorax wall versus the volume of pneumothorax at CT scan [ Time Frame: The ultrasound lung point that the best discriminates a pneumothorax volume more than 11% ]

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients from the Emergency Department Patients admitted to the Hospital Outpatients from the Radiology Department who undergo invasive thoracic procedures

Inclusion Criteria:

  • Radiologic diagnosis of pneumothorax
  • Clinical need to perform a CT scan
  • Ability to perform the lung ultrasound imaging within 20 minutes from the CT study

Exclusion Criteria:

  • age less than 16 years

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01572584

San Luigi Gonzaga University Hospital
Orbassano, Torino, Italy, 10043
Sponsors and Collaborators
San Luigi Gonzaga Hospital
Principal Investigator: Giovanni Volpicelli, MD San Luigi Gonzaga Hospital


Responsible Party: Giovanni Volpicelli, Medical Doctor, Department of Emergency Medicine, San Luigi Gonzaga Hospital Identifier: NCT01572584     History of Changes
Other Study ID Numbers: SLG-181/2011
First Posted: April 6, 2012    Key Record Dates
Last Update Posted: December 19, 2013
Last Verified: December 2013

Keywords provided by Giovanni Volpicelli, San Luigi Gonzaga Hospital:
Lung ultrasound
Chest sonography

Additional relevant MeSH terms:
Pleural Diseases
Respiratory Tract Diseases