Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
|ClinicalTrials.gov Identifier: NCT01572467|
Recruitment Status : Completed
First Posted : April 6, 2012
Last Update Posted : July 14, 2016
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.
|Condition or disease||Intervention/treatment|
|Childhood Germ Cell Tumor Leydig Cell Tumor Ovarian Cancer||Genetic: RNA analysis Genetic: gene expression analysis Genetic: mutation analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis Other: medical chart review|
- To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood|
|Study Start Date :||April 2012|
|Primary Completion Date :||July 2016|
- Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01572467
|Principal Investigator:||Dana A. Hill, MD||Children's Research Institute|