Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
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|ClinicalTrials.gov Identifier: NCT01572467|
Recruitment Status : Completed
First Posted : April 6, 2012
Last Update Posted : July 14, 2016
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.
|Condition or disease||Intervention/treatment|
|Childhood Germ Cell Tumor Leydig Cell Tumor Ovarian Cancer||Genetic: RNA analysis Genetic: gene expression analysis Genetic: mutation analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis Other: medical chart review|
- To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood|
|Study Start Date :||April 2012|
|Actual Primary Completion Date :||July 2016|
- Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01572467
|Principal Investigator:||Dana A. Hill, MD||Children's Research Institute|