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Health Outcomes by Neighborhood - Baltimore

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ClinicalTrials.gov Identifier: NCT01571752
Recruitment Status : Recruiting
First Posted : April 5, 2012
Last Update Posted : February 19, 2018
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Drug Abuse (NIDA) )

Brief Summary:


- Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore neighborhoods. The results could inform prevention efforts, enhance treatment interventions, and improve substance use outcomes.


- To better understand why some people start to use drugs, why some people who use drugs become addicted, and why some people who become addicted enter treatment.


- Individuals at least 18 years of age who are living in the neighborhoods participating in the study.


  • Participants will be screened with a physical exam and medical history. They will be separated into one of four groups: (1) people who do not use drugs, (2) people who have used drugs in the past, (3) people who are using drugs and want treatment, and (4) people who are using drugs and do not want treatment.
  • This study will include two outpatient visits about 12 months apart. Each visit will last about 5 hours. Each study visit may be done in 1 day or in 2 days.
  • At each study visit, participants will provide blood, breath, urine, and saliva samples. They will also have a heart function test and body measurements. They will complete questionnaires about personal and family history.
  • There will be monthly follow-up phone calls between the two visits.

Condition or disease
Drug Abuse/Dependence

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 1550 participants
Time Perspective: Other
Official Title: Health Outcomes by Neighborhood - HON Study Baltimore
Study Start Date : March 8, 2012

Primary Outcome Measures :
  1. The primary outcome measures will be lifetime substance-misuse history and changes in drug-use status across the 12 months between visits. [ Time Frame: 12 Months Between Visits ]

Secondary Outcome Measures :
  1. Secondary outcome measures include: biological assessments of drug use; medical, psychiatric, & social determinants of health; hematologic markers for medical conditions; cumulative stress burden (allostatic load); and personality assess... [ Time Frame: 12 Months Between Visits ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Age at least 18 years. Rationale: Children under 18 will not be included because many of the measures to be administered in this study are not validated for use with children. Furthermore, the research question under investigation is the drug trajectories of adults, over the age of 18. However, there is no intervention in this study that is contraindicated for older adults, and given that addiction in the elderly is understudied, it is important to include elderly individuals.
  • Residence in Baltimore city or one of the surrounding counties. Rationale: Our current geographic mapping technology currently only includes these areas.


-Inability to provide informed consent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01571752

Contact: Karran A Phillips, M.D. (443) 740-2298 phillipsk@mail.nih.gov

United States, Maryland
National Institute on Drug Abuse Recruiting
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
Principal Investigator: Karran A Phillips, M.D. National Institute on Drug Abuse (NIDA)

Responsible Party: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier: NCT01571752     History of Changes
Other Study ID Numbers: 999912472
First Posted: April 5, 2012    Key Record Dates
Last Update Posted: February 19, 2018
Last Verified: December 9, 2017

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute on Drug Abuse (NIDA) ):
Drug Abuse/Dependence
Drug Abuse
Drug Dependence

Additional relevant MeSH terms:
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders