Chemotherapy Resistance and Sensitivity Testing in Lung Tumors
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Chemotherapy Resistance and Sensitivity Testing in Lung Tumors|
- Tumor size [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Tumor response will be evaluated (progression/regression) by CT scan at 3 months from therapy start.
Clinical response to chemotherapy of lung cancer tumor cells versus lung cancer stem cells to standard of care chemo drugs will be evaluated and correlated to predicted drug by ex vivo assay.
|Study Start Date:||October 2011|
|Study Completion Date:||December 2015|
|Primary Completion Date:||May 2014 (Final data collection date for primary outcome measure)|
The chemosensitivity assay will be performed on tissue obtained during the diagnostic fine needle aspiration, core biopsy, or excisional biopsy of the lung lesion. Cancer cells (Bulk of tumor) and Cancer Stem Cells (CSCs) will be isolated and expanded in the laboratory.
The drug screening assay will be used to evaluate the response of the CSCs and of the cancer cells to the various chemotherapy regimens.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01570855
|United States, West Virginia|
|Cabell Huntington Hospital|
|Huntington, West Virginia, United States, 25701|
|Principal Investigator:||Pier P. Claudio, M.D., Ph. D||Marshall University School of Medicine|