Monocytosis and Culprit Vessel in STEMI Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Northwell Health
ClinicalTrials.gov Identifier:
NCT01569646
First received: June 2, 2010
Last updated: March 30, 2012
Last verified: March 2012
  Purpose
Increased white blood cell count at the onset of an acute ST elevation myocardial infarction has been shown to be associated of increased incidence of heart failure and mortality. Now monocytes which are a subset of white blood cells may have a prognostic value for patients presenting with acute ST segment elevation myocardial infarction. A monocyte count of greater than 800/mm3 following acute myocardial infarction has been shown to be associated with increased incidence of left ventricular dysfunction. The investigators study would retrospectively collect data on patients with ST elevation myocardial infarction, looking for an association between high monocyte count and the culprit vessel causing the myocardial infarction. The investigators would also investigate whether monocytosis would be a marker of poor prognosis.

Condition
STEMI

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Significance of Monocytosis and Culprit Vessel in Patients With Acute ST Elevation Myocardial Infarction

Further study details as provided by Northwell Health:

Primary Outcome Measures:
  • Association between monocyte count and culprit vessel [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • clinical outcomes of troponin and monocyte in stemi patients [ Time Frame: 0 - 6 months ] [ Designated as safety issue: No ]

Enrollment: 226
Study Start Date: April 2008
  Eligibility

Ages Eligible for Study:   Child, Adult, Senior
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
STEMI patients,
Criteria

Inclusion Criteria:

  • STEMI

Exclusion Criteria:

  • Patients on antibiotics and steroids
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01569646

Locations
United States, New York
Staten Island University Hospital
Staten Island, New York, United States, 10305
Sponsors and Collaborators
Northwell Health
Investigators
Principal Investigator: Duccio Baldari, MD, FACC Staten Island University Hospital
  More Information

Responsible Party: Northwell Health
ClinicalTrials.gov Identifier: NCT01569646     History of Changes
Other Study ID Numbers: 08-021 
Study First Received: June 2, 2010
Last Updated: March 30, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Northwell Health:
monocytes
culprit vessels

Additional relevant MeSH terms:
Glucuronyl glucosamine glycan sulfate
Anticoagulants
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Hypoglycemic Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 25, 2016