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Effect of Water Rinsing After Topical Fluoride Application on Dental Plaque pH

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ClinicalTrials.gov Identifier: NCT01569165
Recruitment Status : Completed
First Posted : April 3, 2012
Last Update Posted : April 3, 2012
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The aim of this study was to determine whether rinsing with water or cleansing teeth after topical fluoride therapy affect the dental plaque pH.

Condition or disease Intervention/treatment
Dental Caries Procedure: cleansing teeth after topical fluoride therapy

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effect of Water Rinsing After APF Application on Dental Plaque Acidogenicity
Study Start Date : February 2011
Primary Completion Date : October 2011
Study Completion Date : November 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Drinking Water
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: washing after 30 min
washing with water after 30 min following APF treatment
Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: washing after 15 min
washing with water after 15 min following APF treatment
Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: immediately washing with water
immediately washing with water after APF treatment
Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
Experimental: cleansing teeth with cotton roll
cleansing teeth with cotton roll immediately following APF treatment
Procedure: cleansing teeth after topical fluoride therapy
washing with water 0, 15 or 30 min after APF treatment or cleansing teeth with cotton roll immediately following APF treatment.
No Intervention: no fluoride therapy
control group


Outcome Measures

Primary Outcome Measures :
  1. dental plaque PH [ Time Frame: the pH of 48-hour dental plaque was measured using plaque sampling method before (baseline pH) and after sucrose challenge at 5, 10,15,20,30 minutes ]

Secondary Outcome Measures :
  1. maximum pH drop [ Time Frame: 5,10,15,20 and 30 min after sucrose chalenge ]
  2. pH recovery time [ Time Frame: within 30 min after sucrose challenge ]
    time for returning to the baseline pH


Eligibility Criteria

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Ages Eligible for Study:   21 Years to 29 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy people (Without any systemic disease)
  • normal unstimulated salivary rate

Exclusion Criteria:

  • Active dental caries
  • taking any medication with any effect on saliva rate
  • taking antibiotic (or antibacterial mouth rinses) during last 4 weeks
  • usig fluoride mouth rinses during last 2 weeks.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01569165


Locations
Iran, Islamic Republic of
Dental School - Mashhad University of Medical Siences
Mashhad, Khorasan Razavi, Iran, Islamic Republic of
Sponsors and Collaborators
Mashhad University of Medical Sciences
Investigators
Principal Investigator: fatemeh mazhari, Associate Professor Mashhad University of Medical Siences
More Information

Responsible Party: Fatemeh Mazhari, principal investigator, Mashhad University of Medical Sciences
ClinicalTrials.gov Identifier: NCT01569165     History of Changes
Other Study ID Numbers: 89629
First Posted: April 3, 2012    Key Record Dates
Last Update Posted: April 3, 2012
Last Verified: March 2012

Keywords provided by Fatemeh Mazhari, Mashhad University of Medical Sciences:
Acidogenicity
Acidulated phosphate fluoride
dental plaque
water rinsing

Additional relevant MeSH terms:
Dental Caries
Dental Plaque
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Dental Deposits
Fluorides
Fluorides, Topical
Cariostatic Agents
Protective Agents
Physiological Effects of Drugs