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Circulating SIRT6 Expression, Effect on Aging Quality (Sirt6)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01567176
First Posted: March 30, 2012
Last Update Posted: January 18, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Hospices Civils de Lyon
  Purpose
This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Condition Intervention
Aging Biological: Blood sample

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • Sirt6 expression in circulating leukocytes based on the aging quality [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ]
    analysis by quantitative RT-PCR method


Secondary Outcome Measures:
  • hand and forearm muscular strength measurement [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ]
    Hand Grip strength test

  • Physical examination and anthropometric measurement [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ]
    Measurement of the weight, height, waist, hips, blood pressure, pulse.

  • Cognitive assessment [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ]
    MMSE (Mini Mental State Examination), Five-word test, clock drawing

  • Physical Activity questionnaire [ Time Frame: participants will be followed for the duration of the visit, an expected average of 1 day ]
    MAQ (Modifiable Activity Questionnaire)


Enrollment: 60
Study Start Date: March 2012
Study Completion Date: September 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Single Arm Biological: Blood sample
It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Volunteers from the SUVIMAX 2 aging cohort
  • Men and women
  • Older than 60
  • Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
  • Covered by Health Insurance System

Exclusion Criteria:

  • Subject not in compliance with the recommendation of French National Law
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01567176


Locations
France
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre Bénite, France, 69310
Centre de Recherche en Nutrition Humaine
Pierre Bénite, France, 69310
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
Principal Investigator: Martine LAVILLE, Pr Centre de recherche en nutrition humaine Rhone-Alpes
  More Information

Responsible Party: Hospices Civils de Lyon
ClinicalTrials.gov Identifier: NCT01567176     History of Changes
Other Study ID Numbers: 2011.674
First Submitted: March 8, 2012
First Posted: March 30, 2012
Last Update Posted: January 18, 2013
Last Verified: February 2012

Keywords provided by Hospices Civils de Lyon:
Sirtuins
Aging
Metabolic disease