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Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)

This study has been completed.
At Ease USA
Information provided by (Responsible Party):
Creighton University Identifier:
First received: March 26, 2012
Last updated: January 13, 2016
Last verified: January 2016

Veterans with Posttraumatic Stress Disorder (PTSD) will be randomly assigned to either Attention Bias Modification Treatment (ABMT) designed to reduce bias toward threat or a placebo control condition not designed to change attention patterns. Outcome measures will be PTSD, anxiety, depression, and alexithymia symptoms as measured by standard psychological interviews and questionnaires. Participants will also be invited to participate in physiological testing before and after receiving AMBT or placebo to serve as additional outcome measures and assess brain functioning, heart rate, and muscle tension.

The investigators expect to see significant PTSD symptom reduction in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group in which no symptomatic relief is expected. At the end of the study, if ABMT is shown to be effective, we will offer active ABMT to those participants randomly assigned to the placebo arm if they would like to receive the treatment.

Condition Intervention
Posttraumatic Stress Disorder
Behavioral: Attention Bias Modification Training Protocol

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Attention Bias Modification Treatment for Warzone-Related PTSD: A Randomized Clinical Trial Magnetoencephalography Study

Resource links provided by NLM:

Further study details as provided by Creighton University:

Primary Outcome Measures:
  • Will Posttraumatic Stress Disorder and Symptom decrease with intervention [ Time Frame: 8 weeks ]
    Using Clinician-Administered PTSD Scale (CAPS): The clinician-Administered PTSD Scale (CAPS) is a 30-item structured interview that corresponds to the DSM-IV criteria for PTSD (Blake, Weathers, Nagy, Kaloupek, Charney, & Keane, 1995) to assess symptoms of PTSD outcome.

Secondary Outcome Measures:
  • Other psychiatics symptoms (ie Depression, Anger, Anxiety) [ Time Frame: 8 weeks ]
    To assess potential decrease in psychiatric symptoms associated with PTSD, by comparing pre intervention and post intervention scores on psychological measures of deprssion, anger and anxiety.

Enrollment: 51
Study Start Date: April 2012
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Attention Bias Modification Treatment
Attention bias modification training using a computerized spatial attention task (dot-probe) designed to alter threat-bias attention patterns away from threat.
Behavioral: Attention Bias Modification Training Protocol
Attention Bias Modification computerized training sessions administered 2 times per week for 4 weeks making a total of 8 training sessions.
Active Comparator: Attentional Control Training
Attention control training using a computerized spatial attention taks (dot-probe) counter balances training toward and away from threat.
Behavioral: Attention Bias Modification Training Protocol
Attention Bias Modification computerized training sessions administered 2 times per week for 4 weeks making a total of 8 training sessions.


Ages Eligible for Study:   19 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Veterans with Posttraumatic Stress Disorder (PTSD) serving in United States Military after March 20, 2003.

Exclusion Criteria:

  • Schizophrenia
  • Bipolar Disorder
  • Obsessive Compulsive Disorder
  • Head Injury with Loss of Consciousness for more than 30 minutes
  • Active Alcohol/Substance Dependence in past 6 months
  Contacts and Locations
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Please refer to this study by its identifier: NCT01564667

United States, Nebraska
Creighton University
Omaha, Nebraska, United States, 68178
Sponsors and Collaborators
Creighton University
At Ease USA
Principal Investigator: Amy S Badura Brack, PhD Creighton University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Creighton University Identifier: NCT01564667     History of Changes
Other Study ID Numbers: 11-16311
Study First Received: March 26, 2012
Last Updated: January 13, 2016

Keywords provided by Creighton University:
Posttraumatic Stress
Post Traumatic Stress
Attention Bias
Threat Bias

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Mental Disorders processed this record on May 25, 2017