Characterization of Cardiac Hemodynamics During MultiSite Pacing
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The purpose of this study is to evaluate the effects of MultiPoint Pacing (MPP) on cardiac hemodynamics assessed by pressure-volume loop during MPP at implant. NYHA functional class assessment and echocardiographic measurements are performed at 3 months and 12 months post-implant to characterize long-term effect of MPP.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients indicated for standard CRT-D therapy.
Be scheduled to undergo implant of a St Jude Medical CRT-D system with approved standard indication by ESC/EHRA Guidelines
Be in sinus rhythm at the time of enrollment
Have the ability to provide informed consent for study participation and be willing and able to comply with the Clinical Investigation Plan (CIP) described evaluations and follow-up schedule
Exhibit Cheyne-Stokes respiration
Have persistent or permanent atrial fibrillation
Have complete heart block
Be in NYHA IV functional class
Have a recent myocardial infarction within 40 days prior to enrollment
Have undergone cardiac surgery or coronary revascularization procedure within 3 months prior to enrollment or be scheduled for such procedures in the following 7 months
Have had a recent CVA or TIA within 3 months prior to enrollment
Have had intravenous inotropic support in the last 30 days