Postural Instability in Progressive Supranuclear Palsy

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

The purpose of this study is to better understand why individuals with Progressive Supranuclear Palsy (PSP) fall. Understanding the mechanism of gait and balance dysfunction in individuals with PSP may provide us with important early diagnostic tools, allowing for earlier identification of mobility problems and to better evaluate medical therapies aimed at improving motor disability.

The investigators will recruit 10 PSP, 10 PD and 10 healthy controls for the study. All subjects will be asked to come to the OHSU clinic at the Center for Health and Healing for an initial screening visit. They will meet with the primary investigator to conduct a brief interview and physical examination. In addition, they will be asked to answer questions regarding current and past medical illness, how often they fall and what kinds of medications they are on.

Subjects who agree to participate will come to the Oregon Clinical and Translational Research Institute (OCTRI) at OHSU for balance testing. Subjects will be asked to stand or sit on a movable platform with eyes open or closed. Prior to standing on the platform, the investigators will place 6 small sensors on body which are held in place by velcro straps (one on each wrist, ankles, chest and lower back). The platform will then be moved (tilt or slide) while subjects try to keep their balance. During all of the balance tests described above, body movements will be recorded from the sensors on the subjects' body. This data is directly recorded by a computer and analyzed to help us gain better understanding of the subjects' posture and their ability to remain up right.

Condition or disease
Progressive Supranuclear Palsy; Parkinson's Disease

Study Design

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Study Type :	Observational
Estimated Enrollment :	40 participants
Observational Model:	Case Control
Time Perspective:	Cross-Sectional
Official Title:	Postural Instability in Progressive Supranuclear Palsy: Why do Patients With PSP Fall?
Study Start Date :	December 2011

Groups and Cohorts

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Group/Cohort
Progressive Supranuclear Palsy; Patients with a diagnosis of probable or possible PSP as defined by the National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy (NINDS-SPSP) diagnostic criteria.
Parkinson's Disease; Idiopathic PD according to the UK Parkinson‟s Disease Society Brain Bank Clinical Diagnosis Criteria (UKPDSBBCDC)
Healthy Control

Outcome Measures

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Primary Outcome Measures :

1. Relative contributions of vestibular and visual information to postural control in PSP [ Time Frame: Single visit. 2 hours. ]
   To gage the relative contributions of vestibular and visual information to postural control in PSP we will measure body sway using two different tests (LOS and SOT) while a patient stands on a movable force plate within a movable visual surround.

Secondary Outcome Measures :

1. Postural Response Latencies [ Time Frame: Single visit. 2 hours. ]
   Subjects will stand on a movable platform with a movable visual surround. Subjects will be asked to keep their balance while the platform is translated or roated.
2. Gait patterns and postural transitions [ Time Frame: Single visit. 10 minutes. ]
   Subjects will be asked to rise from a chair, walk and turn. Ambulatory balance will be measured by a time up and go test (TUG). Six accelerometers will be placed on the subject and will measure parameters including arm swing, number of steps and turn duration.
3. Perception of vertical and horizontal references [ Time Frame: Single visit. 2 hours. ]
   Subjects will perform two different tasks with their eyes closed while standing and sitting on a force plate that is tilting in the antero-posterior direction. They will perform the following two tasks: 1. Hold a rod parallel to the gravitional vertical 2. Hold a rod perpendicular to the tilting surface so it remains 90 degrees to the surface at all times. Six accelerometers will measure lower and upper body tilt.

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	40 Years to 85 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

OHSU Movement Disorders Clinic Volunteers from the community (Portland, Oregon and surrounding areas)

Criteria

Inclusion Criteria:

1. Diagnosis of probable or possible PSP as defined by the National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy (NINDS-SPSP) diagnostic criteria.
2. Be able to ambulate and stand unassisted for 5 minutes
3. Be able to cooperate with gait and balance testing
4. Be able to give informed consent.

Exclusion Criteria:

1. Cannot exhibit behavior or have dementia that precludes participation in the protocol
2. Cannot have medical or orthopedic illness that, in the investigator's opinion, would impact the patient's postural control or ability to participate in the study.

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Anna M Lovelace, BS, BA	503.494.9531	lovelaca@ohsu.edu
Contact: Bernadette Schoneberg, MD	503.494.7230	schonebu@ohsu.edu

Locations

United States, Oregon
Oregon Health and Science University	Recruiting
Portland, Oregon, United States, 97239
Contact: Anna M Lovelace, BS, BA 503-494-9531 lovelaca@ohsu.edu
Principal Investigator: Bernadette Schoneberg, MD

Sponsors and Collaborators

Oregon Health and Science University

Investigators

Principal Investigator:	Bernadette Schoneberg, MD	Oregon Health and Science University

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:

Related Info 

Responsible Party:	Bernadette Schoneburg, Movement Disorders Fellow, Oregon Health and Science University
ClinicalTrials.gov Identifier:	NCT01563276 History of Changes
Other Study ID Numbers:	IRB00007924
First Posted:	March 26, 2012
Last Update Posted:	March 26, 2012
Last Verified:	March 2012

Keywords provided by Bernadette Schoneburg, Oregon Health and Science University:

Progressive Supranuclear Palsy; PSP; Falls; Gait	Balance; Parkinson's Disease; PD

Additional relevant MeSH terms:

Parkinson Disease; Paralysis; Supranuclear Palsy, Progressive; Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders	Neurodegenerative Diseases; Neurologic Manifestations; Signs and Symptoms; Ophthalmoplegia; Ocular Motility Disorders; Cranial Nerve Diseases; Tauopathies; Eye Diseases