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Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease (SIM)

This study has been completed.
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
Bruno Lemire, Laval University Identifier:
First received: March 20, 2012
Last updated: May 3, 2013
Last verified: May 2013

Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD). Although resistance exercises increase strength and muscle mass in patients with COPD, the response to training appears to be suboptimal in these individuals. A dysregulation in the signaling pathways involved in the regulation of muscle mass could play an important role in this phenomenon.

Hypothesis: Proteins involved in muscle mass regulation will be less activated in the quadriceps of patients with COPD following the acute bout of resistance training exercise compared to healthy age-matched controls.

Condition Intervention
Chronic Obstructive Pulmonary Disease Other: exercise

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Signaling Pathway Activation in the Quadriceps of Patients With COPD After an Acute Bout of Resistance

Resource links provided by NLM:

Further study details as provided by Bruno Lemire, Laval University:

Primary Outcome Measures:
  • Post-exercise signaling proteins phosphorylation level in the quadriceps of COPD patients and age-matched healthy controls [ Time Frame: 2 hours post-exercise ]
    Phosphorylation status of key proteins (Akt, p70, mTOR, p38, JNK, ERK) will be lesser modulated in the quadriceps of patients with COPD compare to healthy controls. The phosphorylated as well as the total protein levels will be measured by western blot. The data will be presented as arbitrary units and compared with values obtained in healthy age-matched healthy controls.

Enrollment: 21
Study Start Date: October 2009
Study Completion Date: April 2013
Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: exercise
    resistance training exercise, 1 session, 3 exercises, 80% of max
Detailed Description:
Our objective is to investigate the impact of an acute bout of resistance training on key signaling pathways involved in the regulation of muscle mass in moderate to severe COPD (FEV1 under 60% of predicted). Key proteins of signaling intramuscular pathways involved in protein synthesis and degradation will be measured before after 72 contractions of the quadriceps. The exercise protocol was designed to match the actual exercise prescription model use in the context of pulmonary rehabilitation. A squat, leg press and leg extension will be done at 80% of max with one minute rest between sets. A biopsy of the quadriceps will be done before and after exercise in order to measure phosphorylated kinases, total protein content and mRNA expressions. All our patients will undergo a thorough baseline assessment in pulmonary capacity, muscle force and body composition.

Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male
  • COPD with an FEV1 of under 60% of predicted
  • non-smoker
  • Between 50 and 75 years old

Exclusion Criteria:

  • All inflammatory disease (HIV, Cancer, renal and cardiac deficiency)
  • Hormonal dysregulation
  • Inferior limb pathology
  • Neuromuscular pathology
  • History of tabacco or alcool abuse
  • Oxygen dependent
  • Recent exacerbation (2 months) of the symptoms of COPD
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Please refer to this study by its identifier: NCT01561625

Canada, Quebec
Quebec City, Quebec, Canada, G1V 4G5
Sponsors and Collaborators
Laval University
Canadian Institutes of Health Research (CIHR)
Principal Investigator: François Maltais, MD Laval University
  More Information

Responsible Party: Bruno Lemire, Étudiant au doctorat, Laval University Identifier: NCT01561625     History of Changes
Other Study ID Numbers: SIM-COPD-20458
Study First Received: March 20, 2012
Last Updated: May 3, 2013

Keywords provided by Bruno Lemire, Laval University:
exercise training

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on August 23, 2017