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Improving Depression Care for Elders: Coordinating Center (IMPACT)

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ClinicalTrials.gov Identifier: NCT01561105
Recruitment Status : Completed
First Posted : March 22, 2012
Last Update Posted : March 28, 2012
Information provided by (Responsible Party):

Study Description
Brief Summary:
Purpose: To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment(IMPACT) collaborative care management program for late-life depression.

Condition or disease Intervention/treatment
Major Depression Dysthymic Disorder Both Major Depression and Dysthymic Disorder Other: IMPACT

Detailed Description:
This study tested an organized method of delivering care for late life depression in primary care. Specifically, the investigators evaluated the effectiveness of this intervention as compared to 'care as usual'. The investigators studied the effect of the intervention on clinical outcomes such as depressive symptoms, functional status, health related quality of life. They also determined the cost-effectiveness of the intervention compared to care as usual.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1801 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: This Was a Five-year Seven-site Trial to Study the Cost-effectiveness of a Population Based Disease Management Program for Late Life Depression in Primary Care.
Study Start Date : January 1999
Primary Completion Date : June 2004
Study Completion Date : June 2004
Arms and Interventions

Arm Intervention/treatment
Experimental: IMPACT Other: IMPACT
IMPACT is a collaborative care management program for late-life depression
Other Name: Improving Mood-Promoting Access to Collaborative Treatment
No Intervention: Care as Usual
Patients received all depression care available to them as part of care as usual in the participating primary care clinics.

Outcome Measures

Primary Outcome Measures :
  1. Severity of depression symptoms
    Severity measured by the 21-item Hopkins Symptom Checklist.

Secondary Outcome Measures :
  1. Functioning
    measured by the Sheehan Health-Related Functioning Index

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Major depression or dysthymia as diagnosed by a structured diagnostic interview.
  • Patient plans to receive primary care at the study clinic for the next year.

Exclusion Criteria:

  • Age under 60.
  • Current symptoms or history of psychosis or mania as determined by structured diagnostic interview.
  • Cognitive impairment as defined by a score less than 23 on a Mini Mental Status Examination.
  • Terminal illness - defined as having a life expectancy of less than 6 months.
  • Active alcohol abuse as determined by a screening interview.
  • High suicide risk as determined by current plan for suicide or a history of more than 3 prior suicide attempts in the past 10 years.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01561105

Sponsors and Collaborators
University of California, Los Angeles
The John A. Hartford Foundation
California HealthCare Foundation
Hogg Foundation
Robert Wood Johnson Foundation
Principal Investigator: Jurgen Unutzer, MD, MPH University of Washington
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jurgen Unutzer, MD, MPH, Professor and Vice-Chair of Psychiatry, Psychiatry and Behavioral Sciences, University of Washington
ClinicalTrials.gov Identifier: NCT01561105     History of Changes
Other Study ID Numbers: JAHF 98297
First Posted: March 22, 2012    Key Record Dates
Last Update Posted: March 28, 2012
Last Verified: March 2012

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Dysthymic Disorder
Pathologic Processes
Behavioral Symptoms
Mood Disorders
Mental Disorders