Effects of Electroconvulsive Therapy (ECT) in Bipolar Depression
The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure the levels of several brain chemicals including, but not limited to, glutamate, glutamine, and N-acetylaspartate, before and after treatment with ECT. In addition to MRS, the investigators will use several other MRI techniques including structural MRI, resting state functional MRI (fMRI), and diffusion tensor imaging (DTI) to measure how the structure and function of the brain changes with ECT.
The investigators hypothesize that the Gln/Glu ratio is increased in the anterior cingulate cortex (ACC), but not the parieto-occipital cortex (POC), following the first ECT treatment.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||A Study of the Acute and Chronic Effects of Electroconvulsive Therapy on Glutamatergic Neurotransmission in Bipolar Depression|
- Gln/Glu ratio following the first ECT treatment [ Time Frame: Participants will undergo an MR scan within 24 hours of their first ECT treatment ]The Gln/Glu ratio is examined in the anterior cingulate cortex (ACC) and the parieto-occipital cortex (POC) following the first ECT treatment.
- The Gln/Glu ratio following the sixth ECT treatment. [ Time Frame: Participants will undergo an MR scan within 24 hours of their sixth ECT treatment, which is approximately two weeks after their first ECT treatment ]The Gln/Glu ratio is examined in both the ACC and POC following the sixth ECT treatment.
|Study Start Date:||April 2011|
|Study Completion Date:||July 2012|
|Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
All study subjects have consented to receive ECT.
Other: No interventions will be used
No interventions will be used
Please refer to this study by its ClinicalTrials.gov identifier: NCT01557933
|Principal Investigator:||Brian P Brennan, M.D.||Mclean Hospital|