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Akershus Cardiac Examination (ACE) 1950 Study (ACE1950)

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ClinicalTrials.gov Identifier: NCT01555411
Recruitment Status : Active, not recruiting
First Posted : March 15, 2012
Last Update Posted : May 7, 2018
Sponsor:
Collaborator:
University Hospital, Akershus
Information provided by (Responsible Party):
Vestre Viken Hospital Trust

Brief Summary:
Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Condition or disease
Atrial Fibrillation Heart Failure Mild Cognitive Impairment Cardiovascular Diseases Cerebrovascular Disorders

Detailed Description:

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway.

Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015. Follow-up and sub-studies are ongoing.

Current status: As per May 2018, follow-up and sub-studies are ongoing.


Study Type : Observational
Actual Enrollment : 3706 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects
Study Start Date : September 2012
Actual Primary Completion Date : May 2015
Estimated Study Completion Date : December 2050

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort
No treatment



Primary Outcome Measures :
  1. Outcomes related to CVD and CV-associated conditions [ Time Frame: Maximum 35 years ]

Secondary Outcome Measures :
  1. Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc. [ Time Frame: Maximum 35 years ]
  2. Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc. [ Time Frame: Maximum 35 years ]
  3. Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc. [ Time Frame: Maximum 35 years ]

Other Outcome Measures:
  1. Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort [ Time Frame: Within 35 years ]
  2. Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort [ Time Frame: Maximum 35 years ]

Biospecimen Retention:   Samples With DNA
Blood samples, including for genetic testing, and urine.


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Ages Eligible for Study:   62 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Residents of Akershus County, Norway, born in 1950.
Criteria

Inclusion Criteria:

  • Resident in Akershus County (as per October 2011, prior to study invitation)
  • Born in the year of 1950
  • Ability to consent to participation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01555411


Locations
Norway
Akershus University Hospital
Lørenskog, Akershus, Norway, 1478
Vestre Viken HT, Baerum Hospital, Department of Medical Research
Sandvika, Akershus, Norway, 3004
Sponsors and Collaborators
Vestre Viken Hospital Trust
University Hospital, Akershus
Investigators
Study Director: Arnljot Tveit, MD, PhD Vestre Viken Hospital Trust, Department of Medical Research
Study Director: Helge Røsjø, MD, PhD University Hospital, Akershus
Principal Investigator: Trygve Berge - member of steering committee, MD Vestre Viken Hospital Trust, Department of Medical Research
Principal Investigator: Pål Smith - member of steering committee, MD, PhD University Hospital, Akershus
Principal Investigator: Kjetil Steine - member of steering committee, MD, PhD University Hospital, Akershus
Principal Investigator: Torbjørn Omland - member of steering committee, MD, PhD University Hospital, Akershus
Principal Investigator: Magnus N Lyngbakken - member of steering committee, MD University Hospital, Akershus

Additional Information:
Publications of Results:
Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Vestre Viken Hospital Trust
ClinicalTrials.gov Identifier: NCT01555411     History of Changes
Other Study ID Numbers: 2011/1475 C
AFIA (initial study name) ( Other Identifier: Vestre Viken Hospital Trust and Akershus University Hospital )
First Posted: March 15, 2012    Key Record Dates
Last Update Posted: May 7, 2018
Last Verified: May 2018

Keywords provided by Vestre Viken Hospital Trust:
Cardiovascular epidemiology
Prospective, observational cohort study
Biomarkers
Cardio- and cerebrovascular imaging

Additional relevant MeSH terms:
Heart Failure
Atrial Fibrillation
Cardiovascular Diseases
Cognitive Dysfunction
Cerebrovascular Disorders
Heart Diseases
Arrhythmias, Cardiac
Pathologic Processes
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases