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The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)

This study has been completed.
Information provided by (Responsible Party):
Tse Hoi Nam, Kwong Wah Hospital Identifier:
First received: March 12, 2012
Last updated: NA
Last verified: March 2012
History: No changes posted
The study hypothesize that parameters of new function machine---'forced oscillation technique' (FOT) can correlate well with the conventional lung function data for measurement of airway resistance and airtrapping in elderly COPD patients.


Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)

Further study details as provided by Kwong Wah Hospital:

Enrollment: 158
Study Start Date: January 2010
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Detailed Description:


Forced oscillation technique (FOT) may be a good supplementary tool to assess lung function in elderly since it is a simple and fast tool requiring minimal patients' cooperation.


To investigate the accuracy of forced oscillation test FOT in assessment of airway resistance and airtrapping in elderly COPD patients by comparing FOT parameters to various conventional lung function parameters including FEV1, FEF 25-75, RV/TLC ratio, IC etc. The best FOT parameter for airway resistance and airtrapping is also determined.


A cross-sectional study conducted in Kwong Wah Hospital, Hong Kong, SAR


COPD patients were recruited from 1st Jan, 2010 to 31st Dec 2011. Both of the lung function tests (forced oscillation technique (FOT) and conventional lung function test) were performed. Parameters of FOT (FRes FDep, RAvr, XAvr, were compared with conventional lung function test for assessment of both airway resistance and airtrapping in COPD subjects. Adjusted FOT parameters (FResRatio and FDep) were also compared with %FEV1 and different GOLD stages.


Comparison between FOT parameters and spirometric parameters was done by correlation test and expressed as Spearman coefficient. ANOVA test is used to compare FOT parameters among different groups of GOLD stages (stage 1 to 4) and groups with various degree of airtrapping (stage 1 to 3). Post hoc analysis was estimated by Bonferroni test.


Ages Eligible for Study:   60 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
COPD patients from both 'in-patient' and 'outpatient clinic' in Kwong Wah Hospital, Hong Kong, China

Inclusion Criteria:

  • COPD patients with previous lung function tests confirming irreversible obstructive pattern

Exclusion Criteria:

  • Lung function test failed to show any obstructive pattern
  • Paitents with co-existing pulmonary diseases including asthma, interstitial lung diseases, lung malignancy etc.
  • Patients with active infectious diseases like tuberculosis
  Contacts and Locations
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  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Tse Hoi Nam, Resident Specialist, Kwong Wah Hospital Identifier: NCT01553812     History of Changes
Other Study ID Numbers: KW/EX-12-030 (48-15)
Study First Received: March 12, 2012
Last Updated: March 12, 2012

Keywords provided by Kwong Wah Hospital:
forced oscillation technique
airway resistance
airtrapping processed this record on April 28, 2017