Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies
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|ClinicalTrials.gov Identifier: NCT01553240|
Recruitment Status : Terminated (Principal Investigator (Dr. Sporn) left the sponsoring institution.)
First Posted : March 14, 2012
Results First Posted : January 13, 2017
Last Update Posted : January 13, 2017
|Condition or disease||Intervention/treatment||Phase|
|Autism Spectrum Disorder Asperger Disorder Pervasive Developmental Disorder||Device: TMS and functional MRI (Magstim)||Not Applicable|
The purpose of this research is to study areas of the brain that may have something to do with repetitive movements (things that people do over and over again) and difficulty communicating with other people (problems with talking to, understanding, or just being in a relationships with other people). The investigators are trying to find out why these brain areas are working differently in people with developmental disorders, such as Autism and how the investigators can one day improve them with new brain stimulation techniques.
The investigators will do screening to make sure that you are eligible for the study. After screening, the investigators will do functional MRI. In this procedure the subject or the control will be looking at videos developed to understand their social communication and language skills. The investigators will be able to understand differences of brain activation between patients and control. The investigators will also use TMS to identify the difference of motor excitability between patients and healthy control.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||8 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies|
|Study Start Date :||June 2007|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||June 2010|
Experimental: TMS and fMRI
Device: TMS and functional MRI (Magstim)
single and paired pulse low frequency TMS. 3T structural MRI scans, amplitude modulated continuous arterial spin labeling( CASL) perfusion imaging sequence optimized for 3T is employed for perfusion MR scans using GE FAIR sequence for parallel imaging.
Other Name: Magstim, Magstim 200, BISTIM Module
- Repetitive Behavior Scale-revised [ Time Frame: during screening ]
- Vineland Maladaptive Behavior Scale [ Time Frame: during screening ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01553240
|United States, New York|
|New York state Psychiatric Institute|
|New York, New York, United States, 10032|
|Principal Investigator:||Alexandra Sporn, MD||NYPI, Columbia University|
|Study Chair:||Sarah Lisanby, MD||NYPI, Columbia University|