An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms
This is a study to learn more about the common cold from studying the nasal secretions produced during a cold or episode of allergic rhinitis.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms in Acute Rhinosinusitis.|
- Nasal Secretion Collection [ Time Frame: 10 minutes ] [ Designated as safety issue: No ]To measure the biophysical properties of nasal secretions for improved mucus clearance.
- Subjective nasal scoring [ Time Frame: 10 Minutes ] [ Designated as safety issue: No ]The Sinus and Nasal Quality of Life Survey (SN-20) questionnaire assess the impact of infection on nasal symptoms, emotion, and activity on a scale of worsening symptoms scored 1 through 7 to provide a quantifiable score capable of comparing both disease severity and the impact of interventions on subjective complaints.
- Nasal Volume [ Time Frame: 15 Minutes ] [ Designated as safety issue: No ]Acoustic rhinometry is used to measure cross-sectional volume of the nasal cavity allowing the calculation of nasal volume.
Biospecimen Retention: Samples With DNA
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||November 2017|
|Estimated Primary Completion Date:||November 2016 (Final data collection date for primary outcome measure)|
Male and female subjects 12 years of age and older with acute nasal discharge fewer then 7 days. Patients must be symptomatic at screening.
Male and female subjects of 12 years of age and older with a history suggesting nasal allergic symptoms for at least 1 year. Patients must be symptomatic at screening.
This study involves collecting and analyzing nasal mucus to see if there are changes in mucus properties during the course of a cold or episode of allergic rhinitis. Outcome measures include SNOT20 questionnaire, nasal secretion collection, acoustic rhinometry on the fifth and fourteenth day of symptoms. The investigators will also collect SNOT20 questionnaires on the tenth and twenty-eighth day.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01553110
|United States, Virginia|
|Virginia Commonwealth University School of Medicine||Recruiting|
|Richmond, Virginia, United States, 23298|
|Contact: Jennifer L Bradley, B.A. (804) 628-2793 firstname.lastname@example.org|
|Principal Investigator: Bruce K Rubin, MEngr, MD, MBA, FRCPC|
|Principal Investigator: Melissa A Yopp, M.S.H.A.|
|Principal Investigator:||Bruce K Rubin, MEngr, MD, MBA, FRCPC||Virginia Commonwealth University School of Medicine|
|Study Director:||Melissa A Yopp, M.S.H.A||Virginia Commonwealth University School of Medicine|