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The Microcirculation in Acute Myocardial Infarction (Micro-AMI) (Micro-AMI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01552564
Recruitment Status : Completed
First Posted : March 13, 2012
Last Update Posted : October 28, 2014
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Condition or disease Intervention/treatment
STEMI Procedure: Index of microvascular resistance Other: Cardiac magnetic resonance Other: Blood markers

Study Design

Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Microcirculation in Acute Myocardial Infarction (Micro-AMI)
Study Start Date : March 2012
Primary Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
STEMI patients
Consecutive patients presenting through the PPCI service
Procedure: Index of microvascular resistance Other: Cardiac magnetic resonance Other: Blood markers


Outcome Measures

Primary Outcome Measures :
  1. Microvascular obstruction [ Time Frame: DAy 2-4 ]
    Microvascular obstruction as a percentage of the left ventricle at 2-4 days.


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
STEMI attending Bristol Heart Institute via the primary PCI service
Criteria

Inclusion Criteria:

  • >18 years old
  • Cardiac symptoms of > 20 mins chest pain or equivalent.
  • ECG criteria consistent with STEMI (STEMI)
  • Proceeding with percutaneous angioplasty
  • Assent/ consent to the study

Exclusion Criteria:

  • Known allergy to adenosine or gadolinium
  • Chronic atrial fibrillation
  • Renal impairment with eGFR <30
  • Contraindication to angiography
  • Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
  • Cardiogenic shock
  • Patients with special communication needs or altered consciousness.
  • Patients who do not give assent/consent to the study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01552564


Locations
United Kingdom
Bristol Heart Institute
Bristol, United Kingdom, BS2 8HW
Sponsors and Collaborators
University of Bristol
More Information

Responsible Party: Elisa McAlindon, Clinical Research Fellow, University of Bristol
ClinicalTrials.gov Identifier: NCT01552564     History of Changes
Other Study ID Numbers: 1625
First Posted: March 13, 2012    Key Record Dates
Last Update Posted: October 28, 2014
Last Verified: October 2014

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases