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Free Fatty Acids: Threshold Repeatability Study

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ClinicalTrials.gov Identifier: NCT01550120
Recruitment Status : Completed
First Posted : March 9, 2012
Last Update Posted : November 25, 2013
Sponsor:
Information provided by (Responsible Party):
Richard Mattes, Purdue University

Study Description
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
This study seeks to determine if non-esterified fatty acid (NEFA) taste detection thresholds change with repeated testing. Threshold testing for NEFA taste has been reported by a number of laboratories, including our own; however, these studies have reported data for only one testing occasion. The investigators seek to conduct repeated testing to measure the test-retest reliability of these methods. The investigators believe that with repeated exposure to NEFA, a person's sensitivity increases. The investigators are also testing the efficiency of testing by two methods (forced-choice ascending trial versus staircase). Additionally, the association between taste responses, diet and BMI will be explored.

Condition or disease
Taste, Non-esterified Fatty Acids

Study Design
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Study Type : Observational
Estimated Enrollment : 48 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Free Fatty Acids: Threshold Repeatability Study
Study Start Date : March 2012
Actual Primary Completion Date : November 2013
Actual Study Completion Date : November 2013
Groups and Cohorts
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information


Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Non-esterified fatty acid detection thresholds in humans [ Time Frame: 6 months ]
  2. BMI [ Time Frame: Baseline ]

Secondary Outcome Measures :
  1. Habitual fat intake [ Time Frame: Baseline ]
    Block Rapid Dietary Fat Screener will be used as well as the ASA-24.

  2. testing method [ Time Frame: 6 months ]
    Comparison of time to maximum sensitivity by participants based on forced-choice versus staircase stimulus presentation techniques.

  3. hunger [ Time Frame: each visit ]
    Visual analog scale


Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Participants between the ages of 18 and 55 years of age from any ethnic background who are in good health and are available for the next three months will be recruited. Additionally, equal numbers of lean and overweight participants will be sought.
Criteria

Inclusion Criteria:

  • 18-55 years old
  • in good health
  • available for three months

Exclusion Criteria:

Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01550120


Locations
United States, Indiana
Purdue University
West Lafayette, Indiana, United States, 47907
Sponsors and Collaborators
Purdue University
Investigators
Principal Investigator: Richard D Mattes, PhD Purdue University
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Richard Mattes, Distinguished Professor, Purdue University
ClinicalTrials.gov Identifier: NCT01550120     History of Changes
Other Study ID Numbers: 055-027
First Posted: March 9, 2012    Key Record Dates
Last Update Posted: November 25, 2013
Last Verified: March 2013

Keywords provided by Richard Mattes, Purdue University:
taste
fat
threshold
sensitivity
human