Extended Rhythm SCreening for AtRial Fibrillation in Cryptogenic Stroke Patients (SCARF)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by Medisch Spectrum Twente.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
B. Oude Velthuis, Medisch Spectrum Twente
ClinicalTrials.gov Identifier:
First received: March 7, 2012
Last updated: April 20, 2012
Last verified: April 2012
Recent studies demonstrated that prolonged rhythm observation increases the detection of atrial fibrillation in patients prior diagnosed as cryptogenic stroke. Detection of atrial fibrillation in these patients has important therapeutic implications for the anticoagulation regimen. However, data on optimal monitoring duration and method of AF detection are limited.

Atrial Fibrillation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Extended Rhythm SCreening for AtRial Fibrillation in Cryptogenic Stroke Patients

Resource links provided by NLM:

Further study details as provided by Medisch Spectrum Twente:

Primary Outcome Measures:
  • Documented Atrial Fibrillation (AF) [ Time Frame: One year ] [ Designated as safety issue: No ]
    The percentage of patients with documented AF based on implantable cardiac monitor registration during a follow-up period of at least 12 months after an episode of cryptogenic stroke.

Secondary Outcome Measures:
  • Time to documented AF [ Time Frame: One year ] [ Designated as safety issue: No ]
    Time to documented AF using an Implantable Loop Recorder (ILR) data

  • Recurrent stroke [ Time Frame: One year ] [ Designated as safety issue: No ]
    Incidence of recurrent stroke

Estimated Enrollment: 50
Study Start Date: September 2011
Estimated Study Completion Date: September 2013
Estimated Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Intensive observation cohort
Patients > 18 years of age diagnosed with a recent episode of cryptogenic stroke with long term rhythm observation using an implantable loop recorder for detecting atrial fibrillation.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted with a ischemic stroke of undetermined etiology

Inclusion Criteria:

  • Patients > 18 years of age Recent episode (≤60 days) of cryptogenic ischemic stroke
  • Undetermined etiology with negative evaluation (including cardioembolism work- up) according to the criteria for the Trial of Org 10172 in Acute Stroke Treatment (TOAST)
  • Implantation of an implantable loop recorder within two months after index event
  • Able of providing informed consent

Exclusion Criteria:

  • Pre-existing indication for vitamin K antagonist
  • Untreated hyperthyroidism
  • Indication for pacemaker implantation, implantable cardioverter defibrillator (ICD) or Cardiac Resynchronisation Therapy (CRT)
  • Severe co-morbidity not likely to complete follow-up for one year
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01550042

Contact: H Verheij +31534872105 h.verheij@mst.nl
Contact: B Oude Velthuis, MD MSc +31534872110 b.oudevelthuis@mst.nl

Medisch Spectrum Twente / Thoraxcenter Recruiting
Enschede, OV, Netherlands, NL7513ER
Contact: Harald Verheij    +31534872105    h.verheij@mst.nl   
Contact: Bob Oude Velthuis, MD MSc    +31534872110    b.oudevelthuis@mst.nl   
Principal Investigator: Bob Oude Velthuis, MD MSc         
Sponsors and Collaborators
Medisch Spectrum Twente
Principal Investigator: Marcoen Scholten, MD PhD Medisch Spectrum Twente
  More Information

Responsible Party: B. Oude Velthuis, Research fellow electrophysiology, Medisch Spectrum Twente
ClinicalTrials.gov Identifier: NCT01550042     History of Changes
Other Study ID Numbers: NL36491.044.11  P11-25 
Study First Received: March 7, 2012
Last Updated: April 20, 2012
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Heart Diseases
Nervous System Diseases
Pathologic Processes
Vascular Diseases

ClinicalTrials.gov processed this record on May 23, 2016