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A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia

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ClinicalTrials.gov Identifier: NCT01549990
Recruitment Status : Completed
First Posted : March 9, 2012
Last Update Posted : January 27, 2015
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

Living-donor kidney transplantation has been considered as the best treatment for patients with end-stage renal disease (ESRD). Kidney donation from living donors has been performed widely under their noble humanity and a belief that donation would not harm the donor. Although the overall evidences proposed that living kidney donor have medical outcomes similar to those in general population, several reports have demonstrated the potential risks for development of hypertension, proteinuria, and ESRD. Thus, all efforts should be concentrated on ensuring their safety and preserving the function of their remained kidney during anesthesia maintenance.

Inhaled anesthetics have been frequently used for the induction and maintenance of general anesthesia. The metabolism of certain inhaled anesthetics can produce inorganic fluoride, which may be directly nephrotoxic through impairments of renal concentrating ability. The typical inhaled anesthetics commonly used nowadays are sevoflurane and desflurane. The defluorination of sevoflurane can results in increased serum inorganic fluoride ion concentrations, but any neprhotoxic effect of sevoflurane has not been proven yet in human. On the other hand, desflurane is extremely resistant to defluorination, and desflurane does not appear to be nephrotoxic.

The inhaled anesthetics which are currently used in general anesthesia have no clinical evidence of nephrotoxicity, but the possible risks cannot be excluded entirely, especially in the patients who one kidney is donated. The purpose of the current retrospective, single center study was to evaluate and compare postoperative renal function of living kidney donor after nephrectomy under sevoflurane or desflurane anesthesia, and make evidence-based recommendations of proper inhaled anesthetics for anesthesia of living kidney donor.


Condition or disease Intervention/treatment
Nephrectomy,Kidney Donation Drug: Sevoflurane Drug: desflurane

Study Design

Study Type : Observational
Actual Enrollment : 236 participants
Observational Model: Cohort
Time Perspective: Retrospective
Study Start Date : February 2012
Primary Completion Date : October 2012
Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anesthesia
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
Sevoflurane group
donors who went through donor nephrectomy under general anesthesia with sevoflurane
Drug: Sevoflurane
maintenance of general anesthesia with sevoflurane
desflurane group
donors who went through donor nephrectomy under general anesthesia with desflurane
Drug: desflurane
maintenance of general anesthesia with desflurane


Outcome Measures

Primary Outcome Measures :
  1. Postoperative renal function of living kidney donor after nephrectomy under sevoflurane or desflurane anesthesia [ Time Frame: Participants will be followed for postoperative period, approximate 1 week through chart review. ]
    We collect laboratory data of the patients which were underwent at preoperative period and during postoperative periods. The laboratory data includes hemoglobin (Hb), hematocrit (Hct), platelet, prothrombin time (PT), albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine (Cr) and estimated glomerular filtration rate (eGFR) which was calculated by the Modification of Diet in Renal Disease (MDRD) formula with age, gender, race, and serum creatinine as variables.


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
From January 2006 through December 2011, donors who went through nephrectomy for kidney donation
Criteria

Inclusion Criteria:

  • donors who went through nephrectomy for kidney donation under general anesthesia with sevoflurane or desflurane

Exclusion Criteria:

  • donors who went through nephrectomy for kidney donation under general anesthesia with other inhaled anesthetics except sevoflurane and desflurane
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01549990


Locations
Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
More Information

Publications:
Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT01549990     History of Changes
Other Study ID Numbers: 4-2012-0012
First Posted: March 9, 2012    Key Record Dates
Last Update Posted: January 27, 2015
Last Verified: January 2015

Additional relevant MeSH terms:
Anesthetics
Sevoflurane
Desflurane
Isoflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General